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    crol crooked legs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34592, updated on 17-Dec-2024

    Summary

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    Official Symbol
    crolprovided by FlyBase
    Official Full Name
    crooked legsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020309
    Locus tag
    Dmel_CG14938
    See related
    AllianceGenome:FB:FBgn0020309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.74; anon-EST:Liang-2.48; CG14938; clone 1.74; clone 2.48; croI; Crol; crol alpha; crol beta; crol gamma; Dmel\CG14938; l(2)04418; l(2)s2346; ORE-15
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; negative regulation of Wnt signaling pathway; and regulation of DNA-templated transcription. Located in heterochromatin and nucleus. Is expressed in several structures, including antennal anlage; anterior endoderm; cuboidal/columnar epithelium; embryonic/larval midgut primordium; and ganglia. Orthologous to human ZNF287 (zinc finger protein 287) and ZNF83 (zinc finger protein 83). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crol in Genome Data Viewer
    Location:
    33A1-33A2; 2-45 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11794327..11809438, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11794327..11809438, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 33B Neighboring gene Cyclin Y Neighboring gene Phosphodiesterase 1c Neighboring gene extra sexcombs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Ward RE, et al. Dev Biol, 2003 Apr 15. PMID 12679111
    2. The Ecdysone receptor constrains wingless expression to pattern cell cycle across the Drosophila wing margin in a Cyclin B-dependent manner. Mitchell NC, et al. BMC Dev Biol, 2013 Jul 13. PMID 23848468, Free PMC Article
    3. Identifying potential PARIS homologs in D. melanogaster. Merzetti EM, et al. Genet Mol Res, 2016 Nov 3. PMID 27819722
    4. Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Liu D, et al. Genetics, 2010 Apr. PMID 20100936, Free PMC Article
    5. The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis. D'Avino PP, et al. Dev Biol, 2000 Apr 15. PMID 10753511

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crol contributes to PRE-mediated repression and Polycomb group proteins recruitment in Drosophila.
      Title: Crol contributes to PRE-mediated repression and Polycomb group proteins recruitment in Drosophila.
    2. Crol links steroid hormone signals to Wg signalling and the regulation of crucial cell cycle targets.
      Title: The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    crooked legs
    Names
    CG14938-PA
    CG14938-PB
    CG14938-PC
    CG14938-PD
    CG14938-PE
    CG14938-PF
    CG14938-PG
    CG14938-PH
    CG14938-PI
    crol-PA
    crol-PB
    crol-PC
    crol-PD
    crol-PE
    crol-PF
    crol-PG
    crol-PH
    crol-PI
    crooked-legs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11794327..11809438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273462.1 → NP_001260391.1  crooked legs, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCY3
      Conserved Domains (3) summary
      COG5048
      Location:247 → 639
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:403 → 428
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001273461.1 → NP_001260390.1  crooked legs, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260390.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD94
      Conserved Domains (2) summary
      COG5048
      Location:300 → 670
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001273463.1 → NP_001260392.1  crooked legs, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFM9
      Conserved Domains (2) summary
      COG5048
      Location:179 → 426
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326 → 346
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_164971.2 → NP_723687.1  crooked legs, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723687.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRK4
      Related
      FBpp0079844
      Conserved Domains (3) summary
      COG5048
      Location:300 → 641
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:391 → 411
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:431 → 456
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001273464.1 → NP_001260393.1  crooked legs, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260393.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61360, Q9VKF1
      Conserved Domains (2) summary
      COG5048
      Location:300 → 723
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:391 → 411
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001259064.2 → NP_001245993.1  crooked legs, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61360, Q9VKF1
      Conserved Domains (2) summary
      COG5048
      Location:300 → 723
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:391 → 411
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_057896.4 → NP_477244.1  crooked legs, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477244.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61362
      Related
      FBpp0079847
      Conserved Domains (3) summary
      COG5048
      Location:321 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:185 → 205
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:197 → 222
      zf-H2C2_2; Zinc-finger double domain

    8. NM_057897.4 → NP_477245.1  crooked legs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477245.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61361
      Related
      FBpp0079846
      Conserved Domains (2) summary
      COG5048
      Location:247 → 631
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:391 → 411
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_057895.4 → NP_477243.1  crooked legs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61360, Q9VKF1
      Related
      FBpp0079845
      Conserved Domains (2) summary
      COG5048
      Location:300 → 723
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:391 → 411
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCY3 M9PCY3
    M9PD94 M9PD94
    M9PFM9 M9PFM9
    O61360 O61360
    O61361 O61361
    O61362 O61362
    Q8MRK4 Q8MRK4
    Q95R99 Q95R99

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