U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hira hira [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31680, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hiraprovided by FlyBase
    Official Full Name
    hiraprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022786
    Locus tag
    Dmel_CG12153
    See related
    AllianceGenome:FB:FBgn0022786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12153; Dhh; dhira; dHira; Dmel\CG12153; hira; HIRA; ssm
    Summary
    Enables chromatin binding activity and histone chaperone activity. Involved in sperm DNA decondensation. Located in germinal vesicle and male germ cell nucleus. Is expressed in nurse cell; oocyte; organism; and ovary. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hira in Genome Data Viewer
    Location:
    7B7-7B7; 1-20 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7722119..7725917)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7616152..7619950)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Checkpoint suppressor 1-like Neighboring gene long non-coding RNA:CR43287 Neighboring gene uncharacterized protein Neighboring gene NELF-B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation and characterization of a new gene encoding a member of the HIRA family of proteins from Drosophila melanogaster. Kirov N, et al. Gene, 1998 Jun 8. PMID 9611274
    2. Cloning, chromosome mapping and expression analysis of the HIRA gene from Drosophila melanogaster. Llevadot R, et al. Biochem Biophys Res Commun, 1998 Aug 19. PMID 9712723
    3. Wolbachia-induced cytoplasmic incompatibility is associated with decreased Hira expression in male Drosophila. Zheng Y, et al. PLoS One, 2011 Apr 29. PMID 21559343, Free PMC Article
    4. Mitotic fidelity requires transgenerational action of a testis-restricted HP1. Levine MT, et al. Elife, 2015 Jul 7. PMID 26151671, Free PMC Article
    5. Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis. Blythe SA, et al. Elife, 2016 Nov 23. PMID 27879204, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that the HIRA B domain is not essential for paternal chromatin assembly in drosophila.
      Title: ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization.
    2. Intellectual disability-associated BRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3.
      Title: Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3.
    3. we demonstrate that HIRA and YEM proteins interact and are mutually dependent for their targeting to the decondensing male pronucleus.
      Title: Drosophila Yemanuclein and HIRA cooperate for de novo assembly of H3.3-containing nucleosomes in the male pronucleus.
    4. Hira plays an important role in the interaction of Wolbachia and its insect host
      Title: Wolbachia-induced cytoplasmic incompatibility is associated with decreased Hira expression in male Drosophila.
    5. The only essential function of HIRA is the assembly of paternal chromatin during male pronucleus formation.
      Title: The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization.
    6. the histone chaperone protein HIRA is required for nucleosome assembly during sperm nucleus decondensation
      Title: The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone chaperone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm DNA decondensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in germinal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    hira
    Names
    CG12153-PA
    Hira-PA
    drosophila hira homolog
    drosophila homolog of HIRA
    sesame

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7722119..7725917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132173.3 → NP_572401.2  hira [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572401.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17468, O46105, O77144, Q5U0S5, Q8T0C3, Q9W3Q3
      Related
      FBpp0071028
      Conserved Domains (5) summary
      COG2319
      Location:12 → 370
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:14 → 349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam07569
      Location:629 → 820
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:423 → 442
      HIRA_B; HIRA B motif
      sd00039
      Location:16 → 68
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17468.2 O17468

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools