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    RSG7 Regulator of G-protein signaling 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSG7provided by FlyBase
    Official Full Name
    Regulator of G-protein signaling 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0024941
    Locus tag
    Dmel_CG9108
    See related
    AllianceGenome:FB:FBgn0024941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9108; Dmel\CG9108; dRGS7; RGS7
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Predicted to be active in cytoplasm and neuron projection. Is expressed in adult head. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS6 (regulator of G protein signaling 6) and RGS7 (regulator of G protein signaling 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RSG7 in Genome Data Viewer
    Location:
    15A11-15B1; 1-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16838173..16844433, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16732206..16738466, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44129 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nitrogen permease regulator-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dRGS7 encodes a Drosophila homolog of EGL-10 and vertebrate RGS7. Elmore T, et al. DNA Cell Biol, 1998 Nov. PMID 9839808
    2. Divergence of RGS proteins: evidence for the existence of six mammalian RGS subfamilies. Zheng B, et al. Trends Biochem Sci, 1999 Nov. PMID 10542401
    3. Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. Im SH, et al. Elife, 2015 Nov 17. PMID 26575288, Free PMC Article
    4. GWAS for Lifespan and Decline in Climbing Ability in Flies upon Dietary Restriction Reveal decima as a Mediator of Insulin-like Peptide Production. Wilson KA, et al. Curr Biol, 2020 Jul 20. PMID 32502405, Free PMC Article
    5. Dynamic, mating-induced gene expression changes in female head and brain tissues of Drosophila melanogaster. Dalton JE, et al. BMC Genomics, 2010 Oct 6. PMID 20925960, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 7
    Names
    CG9108-PA
    CG9108-PB
    RSG7-PA
    RSG7-PB
    regulator of G-protein signalling 7
    regulator of g protein signaling 7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16838173..16844433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258793.3 → NP_001245722.1  regulator of G-protein signaling 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76453, Q5BI81, Q9VXA3
      Conserved Domains (3) summary
      smart00224
      Location:432 → 493
      GGL; G protein gamma subunit-like motifs
      cd08705
      Location:504 → 627
      RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
      cd04450
      Location:222 → 309
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    2. NM_078656.4 → NP_523380.2  regulator of G-protein signaling 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523380.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76453, Q5BI81, Q9VXA3
      Conserved Domains (3) summary
      smart00224
      Location:432 → 493
      GGL; G protein gamma subunit-like motifs
      cd08705
      Location:504 → 627
      RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
      cd04450
      Location:222 → 309
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KPI3 Q7KPI3
    Q9VXA3 Q9VXA3

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