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    CG7857 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39671, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG7857provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026738
    Locus tag
    Dmel_CG7857
    See related
    AllianceGenome:FB:FBgn0026738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-Becker1; Dmel\CG7857; Q9VUN9
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in positive regulation of translational initiation in response to stress. Located in cytosol and nucleolus. Orthologous to human OTUD6A (OTU deubiquitinase 6A) and OTUD6B (OTU deubiquitinase 6B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7857 in Genome Data Viewer
    Location:
    71D3-71D3; 3-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15503600..15504894, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15496700..15497994, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene gdl-ORF39 Neighboring gene Z600 Neighboring gene gonadal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress. Villa S, et al. Nat Commun, 2024 Aug 11. PMID 39127721, Free PMC Article
    2. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
    3. Deubiquitylases from genes to organism. Clague MJ, et al. Physiol Rev, 2013 Jul. PMID 23899565
    4. Systematic analysis of the physiological importance of deubiquitinating enzymes. Tsou WL, et al. PLoS One, 2012. PMID 22937016, Free PMC Article
    5. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster. Páhi ZG, et al. Sci Rep, 2022 Apr 7. PMID 35393473, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translational initiation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7857-PA
    NP_648769.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15503600..15504894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140512.2 → NP_648769.2  uncharacterized protein Dmel_CG7857 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648769.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRW3, Q9VUN9
      Related
      FBpp0075358, FBtr0075605
      Conserved Domains (2) summary
      COG5539
      Location:17 → 307
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
      pfam02338
      Location:178 → 305
      OTU; OTU-like cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRW3 Q8MRW3
    Q9VUN9 Q9VUN9
    Q9XYY2 Q9XYY2

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