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    ND-ASHI NADH dehydrogenase (ubiquinone) ASHI subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-ASHIprovided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) ASHI subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029888
    Locus tag
    Dmel_CG3192
    See related
    AllianceGenome:FB:FBgn0029888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3192; Dmel\CG3192; dNDUFB8; Ndufb8; NDUFB8; NIAM; Q9W3X7
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 32. Orthologous to human NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-ASHI in Genome Data Viewer
    Location:
    6C5-6C5; 1-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6677262..6679118, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6571295..6573151, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Minichromosome maintenance 6 Neighboring gene Fumarase 1 Neighboring gene Fumarase 2 Neighboring gene PTEN-induced putative kinase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture. Graham LC, et al. Mol Neurodegener, 2017 Oct 27. PMID 29078798, Free PMC Article
    2. Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis. Murari A, et al. iScience, 2021 Aug 20. PMID 34386730, Free PMC Article
    3. Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. Ebanks B, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769041, Free PMC Article
    4. Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates. Appocher C, et al. Hum Mol Genet, 2014 Dec 20. PMID 25096240
    5. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) ASHI subunit
    Names
    CG3192-PA
    CG3192-PB
    CG3192-PC
    NADH ubiquinone oxidoreductase ASHI
    NADH-ubiquinone oxidoreductase ASHI subunit
    NADH:ubiquinone oxidoreductase ASHI subunit
    ND-ASHI-PA
    ND-ASHI-PB
    ND-ASHI-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6677262..6679118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132110.2 → NP_572338.1  NADH dehydrogenase (ubiquinone) ASHI subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQD2, Q9W3X7
      Related
      FBpp0070950
      Conserved Domains (1) summary
      pfam05821
      Location:25 → 164
      NDUF_B8; NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

    2. NM_001031877.2 → NP_001027048.1  NADH dehydrogenase (ubiquinone) ASHI subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQD2, Q9W3X7
      Conserved Domains (1) summary
      pfam05821
      Location:25 → 164
      NDUF_B8; NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

    3. NM_001298022.1 → NP_001284951.1  NADH dehydrogenase (ubiquinone) ASHI subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQD2, Q9W3X7
      Conserved Domains (1) summary
      pfam05821
      Location:25 → 164
      NDUF_B8; NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3X7 Q9W3X7

    Gene LinkOut

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