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    Cdc50 Cell division cycle 50 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc50provided by FlyBase
    Official Full Name
    Cell division cycle 50provided by FlyBase
    Primary source
    FLYBASE:FBgn0030752
    Locus tag
    Dmel_CG9947
    See related
    AllianceGenome:FB:FBgn0030752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CDC50; CG9947; Dmel\CG9947
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to several human genes including TMEM30A (transmembrane protein 30A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdc50 in Genome Data Viewer
    Location:
    14C4-14C6; 1-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16438680..16441296, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16331454..16335329, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene TNF-receptor-associated factor-like Neighboring gene Annexin B11 Neighboring gene hangover Neighboring gene rings lost Neighboring gene eukaryotic translation initiation factor 2 subunit alpha Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylserine Externalization Results from and Causes Neurite Degeneration in Drosophila. Sapar ML, et al. Cell Rep, 2018 Aug 28. PMID 30157423, Free PMC Article
    2. The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons. Ji H, et al. Proc Natl Acad Sci U S A, 2023 Jun 13. PMID 37276397, Free PMC Article
    3. Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning. Sung HH, et al. Nat Commun, 2024 Aug 27. PMID 39191750, Free PMC Article
    4. Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration. Ji H, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35058357, Free PMC Article
    5. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Shiomi A, et al. Cell Rep, 2021 Jun 8. PMID 34107250

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle 50
    Names
    CG9947-PA
    CG9947-PB
    Cdc50-PA
    Cdc50-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16438680..16441296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298398.2 → NP_001285327.1  cell division cycle 50, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285327.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8STD2, X2JKP3
      Conserved Domains (1) summary
      pfam03381
      Location:67 → 340
      CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

    2. NM_132900.3 → NP_573128.2  cell division cycle 50, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573128.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8STD2, Q9VXG0
      Related
      FBpp0074076
      Conserved Domains (1) summary
      pfam03381
      Location:67 → 340
      CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8STD2 Q8STD2
    Q9VXG0 Q9VXG0
    X2JKP3 X2JKP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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