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    wcy wacky [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wcyprovided by FlyBase
    Official Full Name
    wackyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030812
    Locus tag
    Dmel_CG8949
    See related
    AllianceGenome:FB:FBgn0030812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BP1032; CG34014; CG8949; Dmel\CG8949; XE14
    Summary
    Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Involved in habituation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Located in lysosome and nucleus. Is expressed in embryonic/larval fat body. Used to study DeSanto-Shinawi syndrome. Human ortholog(s) of this gene implicated in DeSanto-Shinawi syndrome. Orthologous to human WAC (WW domain containing adaptor with coiled-coil). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wcy in Genome Data Viewer
    Location:
    15E1-15E1; 1-57 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17068717..17077897, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16962750..16971930, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila. Lugtenberg D, et al. Eur J Hum Genet, 2016 Aug. PMID 26757981, Free PMC Article
    2. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Xu GM, et al. Genomics, 2002 Jan. PMID 11827461
    3. Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Kepler LD, et al. Neurobiol Learn Mem, 2020 May. PMID 32147587
    4. WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. David-Morrison G, et al. Dev Cell, 2016 Jan 25. PMID 26812014, Free PMC Article
    5. The gut-microbiota-brain axis in autism: what Drosophila models can offer? Salim S, et al. J Neurodev Disord, 2021 Sep 15. PMID 34525941, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal knockdown of Drosophila CG8949 resulted in impaired learning.
      Title: De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in habituation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wacky
    Names
    CG8949-PA
    CG8949-PC
    CG8949-PD
    CG8949-PE
    CG8949-PF
    CG8949-PG
    wcy-PA
    wcy-PC
    wcy-PD
    wcy-PE
    wcy-PF
    wcy-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17068717..17077897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258796.2 → NP_001245725.1  wacky, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245725.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q32KD5, Q9VX88
      Conserved Domains (1) summary
      cd00201
      Location:242 → 271
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    2. NM_132959.3 → NP_573187.2  wacky, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573187.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q32KD5, Q9VX88
      Conserved Domains (1) summary
      cd00201
      Location:242 → 271
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    3. NM_001272708.1 → NP_001259637.1  wacky, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHX3
      Conserved Domains (1) summary
      cd00201
      Location:242 → 271
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    4. NM_001103538.4 → NP_001097008.2  wacky, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097008.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY73
      Conserved Domains (1) summary
      cd00201
      Location:242 → 271
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    5. NM_001272706.2 → NP_001259635.1  wacky, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259635.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEY4
      Conserved Domains (1) summary
      cd00201
      Location:242 → 271
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    6. NM_001272707.1 → NP_001259636.1  wacky, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHE3
      Conserved Domains (1) summary
      cd00201
      Location:284 → 313
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEY4 M9PEY4
    M9PHE3 M9PHE3
    M9PHX3 M9PHX3
    Q9VX88.2 Q9VX88
    R9PY73 R9PY73

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