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    CG6788 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6788provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030880
    Locus tag
    Dmel_CG6788
    See related
    AllianceGenome:FB:FBgn0030880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF48780; Dmel\CG6788; FBpp0074269
    Summary
    Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in brain small vessel disease; cardiovascular system disease (multiple); congenital afibrinogenemia; end stage renal disease; and multiple myeloma. Orthologous to several human genes including FGB (fibrinogen beta chain); FGG (fibrinogen gamma chain); and FGL2 (fibrinogen like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6788 in Genome Data Viewer
    Location:
    16F1-16F1; 1-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17888177..17889404)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17782210..17783437)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene minibrain Neighboring gene uncharacterized protein Neighboring gene Glutathione synthetase 1 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A critical assessment of storytelling: gene ontology categories and the importance of validating genomic scans. Pavlidis P, et al. Mol Biol Evol, 2012 Oct. PMID 22617950
    2. Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Ortiz JG, et al. Toxicol Sci, 2009 Feb. PMID 18779381, Free PMC Article
    3. Identification and characterization of the fibrinogen-like domain of fibrinogen-related proteins in the mosquito, Anopheles gambiae, and the fruitfly, Drosophila melanogaster, genomes. Wang X, et al. BMC Genomics, 2005 Sep 8. PMID 16150145, Free PMC Article
    4. Evolution and potential function of fibrinogen-like domains across twelve Drosophila species. Middha S, et al. BMC Genomics, 2008 May 30. PMID 18513432, Free PMC Article
    5. Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster. Sambandan D, et al. Genetics, 2008 Jun. PMID 18505870, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6788-PA
    Fibrinogen-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17888177..17889404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133026.1 → NP_573254.1  uncharacterized protein Dmel_CG6788 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX04
      Related
      FBpp0074269, FBtr0074495
      Conserved Domains (1) summary
      cd00087
      Location:160 → 356
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX04 Q9VX04

    Gene LinkOut

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