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    FucTB alpha1,3-fucosyltransferase B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FucTBprovided by FlyBase
    Official Full Name
    alpha1,3-fucosyltransferase Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032117
    Locus tag
    Dmel_CG4435
    See related
    AllianceGenome:FB:FBgn0032117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4435; CT14430; Dmel\CG4435
    Summary
    Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in Golgi membrane. Is expressed in adult head; head mesoderm; organism; and trunk mesoderm. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to several human genes including FUT10 (fucosyltransferase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FucTB in Genome Data Viewer
    Location:
    30B3-30B3; 2-35 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9428669..9431052, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9428669..9431052, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Multicopper oxidase 1 Neighboring gene Fat body protein 2 Neighboring gene uncharacterized protein Neighboring gene scattered Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S28-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseadish peroxidase epitope. Fabini G, et al. J Biol Chem, 2001 Jul 27. PMID 11382750
    2. Modulation of neural carbohydrate epitope expression in Drosophila melanogaster cells. Rendic D, et al. J Biol Chem, 2006 Feb 10. PMID 16314421
    3. Neural-specific α3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation. Rendić D, et al. Glycobiology, 2010 Nov. PMID 20688784, Free PMC Article
    4. Glycosylation of proteins in plants and invertebrates. Wilson IB. Curr Opin Struct Biol, 2002 Oct. PMID 12464307
    5. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha1,3-fucosyltransferase B
    Names
    CG4435-PA
    CG4435-PC
    CG4435-PD
    FucTB-PA
    FucTB-PC
    FucTB-PD
    alpha1,3-fucosyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9428669..9431052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298850.1 → NP_001285779.1  alpha1,3-fucosyltransferase B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QQB0, Q8I928, Q9VLC1
      UniProtKB/TrEMBL
      X2J5D8
      Conserved Domains (2) summary
      pfam00852
      Location:178 → 314
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:61 → 139
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. NM_135444.5 → NP_609288.4  alpha1,3-fucosyltransferase B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609288.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QQB0, Q8I928, Q9VLC1
      UniProtKB/TrEMBL
      X2J5D8
      Conserved Domains (2) summary
      pfam00852
      Location:178 → 314
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:61 → 139
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    3. NM_001298851.1 → NP_001285780.1  alpha1,3-fucosyltransferase B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQY2
      Conserved Domains (1) summary
      pfam00852
      Location:2 → 77
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9EQY2 B9EQY2
    Q9VLC1.2 Q9VLC1
    X2J5D8 X2J5D8

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