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    CG5676 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5676provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032200
    Locus tag
    Dmel_CG5676
    See related
    AllianceGenome:FB:FBgn0032200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD31953; Dmel\CG5676; FUNDC1; LD31953
    Summary
    Involved in mitochondrial fusion and mitophagy. Predicted to be active in mitochondrial outer membrane. Is expressed in adult head and adult heart. Orthologous to several human genes including FUNDC2 (FUN14 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5676 in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10254610..10255891, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10254610..10255891, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene basket Neighboring gene uncharacterized protein Neighboring gene Ror Neighboring gene Phosphatase and tensin homolog Neighboring gene Repressor splicing factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FUNDC1 collaborates with PINK1 in regulating mitochondrial Fission and compensating for PINK1 deficiency. Xu J, et al. Biochem Biophys Res Commun, 2023 Dec 20. PMID 37931419
    2. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Huang H, et al. Development, 1999 Dec. PMID 10556061
    3. Role of Drosophila HP1 in euchromatic gene expression. Cryderman DE, et al. Dev Dyn, 2005 Mar. PMID 15704177
    4. Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis. Ham SJ, et al. Sci Adv, 2021 Jul. PMID 34244144, Free PMC Article
    5. Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. Yatsenko AS, et al. BMC Med, 2020 Jan 21. PMID 31959160, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5676-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10254610..10255891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135518.3 → NP_609362.1  uncharacterized protein Dmel_CG5676 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL16
      Related
      FBpp0079675
      Conserved Domains (1) summary
      pfam04930
      Location:24 → 153
      FUN14; FUN14 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL16 Q9VL16

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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