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    CG17134 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17134provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032304
    Locus tag
    Dmel_CG17134
    See related
    AllianceGenome:FB:FBgn0032304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17134
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be active in lysosome. Orthologous to several human genes including CTSE (cathepsin E); PGA3 (pepsinogen A3); and PGA4 (pepsinogen A4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17134 in Genome Data Viewer
    Location:
    32B1-32B1; 2-43 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10820705..10821967)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10820705..10821967)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44581 Neighboring gene Nitric oxide synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4987 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase. Kotani N, et al. J Biochem, 2005 Mar. PMID 15809332
    2. Nitric oxide synthase is not essential for Drosophila development. Yakubovich N, et al. Curr Biol, 2010 Feb 23. PMID 20178753, Free PMC Article
    3. Essential function of nitric oxide synthase in Drosophila. Regulski M, et al. Curr Biol, 2004 Oct 26. PMID 15498477
    4. Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling. Rabinovich D, et al. Cell, 2016 Jan 14. PMID 26771490, Free PMC Article
    5. Drosophila Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis. Zhu L, et al. RNA Biol, 2019 Oct. PMID 31195914, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17134-PA
    NP_609458.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10820705..10821967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135614.3 → NP_609458.1  uncharacterized protein Dmel_CG17134 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKP6
      Related
      FBpp0079729
      Conserved Domains (2) summary
      pfam00026
      Location:75 → 388
      Asp; Eukaryotic aspartyl protease
      cl11403
      Location:70 → 386
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKP6 Q9VKP6

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