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    CG7741 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36208, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7741provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033615
    Locus tag
    Dmel_CG7741
    See related
    AllianceGenome:FB:FBgn0033615
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7741
    Summary
    Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7741 in Genome Data Viewer
    Location:
    47F1-47F1; 2-64 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11301916..11305607)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7189421..7193112)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene defective in the avoidance of repellents Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 47b Neighboring gene Farnesyl pyrophosphate synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene no mechanoreceptor potential A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [LTR retrotransposons as a source of promoters in the Drosophila genome]. Makunin IV, et al. Genetika, 2010 Sep. PMID 21061618
    2. nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures. Chung YD, et al. Neuron, 2001 Feb. PMID 11239432
    3. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Asha H, et al. Genetics, 2003 Jan. PMID 12586708, Free PMC Article
    4. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA lariat debranching enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7741-PA
    CG7741-PB
    CG7741-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11301916..11305607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136826.3 → NP_610670.2  uncharacterized protein Dmel_CG7741, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610670.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8J0, B6IDJ3, Q86NM0
      Related
      FBpp0087219
      Conserved Domains (3) summary
      cd07380
      Location:29 → 249
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:466 → 543
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:320 → 428
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

    2. NM_001259334.2 → NP_001246263.1  uncharacterized protein Dmel_CG7741, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246263.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6X7
      Conserved Domains (3) summary
      cd07380
      Location:8 → 228
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:445 → 522
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:299 → 407
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

    3. NM_001299382.1 → NP_001286311.1  uncharacterized protein Dmel_CG7741, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH71
      Conserved Domains (3) summary
      pfam04676
      Location:278 → 355
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:132 → 240
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
      cl13995
      Location:2 → 61
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6X7 A0A0B4K6X7
    A1Z8J0.1 A1Z8J0
    E8NH71 E8NH71

    Gene LinkOut

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