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    AttC Attacin-C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36484, updated on 24-Dec-2024

    Summary

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    Official Symbol
    AttCprovided by FlyBase
    Official Full Name
    Attacin-Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041579
    Locus tag
    Dmel_CG4740
    See related
    AllianceGenome:FB:FBgn0041579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    att; Att; att C; attacin; attacin c; Attacin C; attC; C; CG4740; DIM 16; DIM-16; Dmel\CG4740; MPAC
    Summary
    Involved in antibacterial humoral response and defense response to Gram-positive bacterium. Located in extracellular space. Is expressed in embryonic/larval hemolymph. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AttC in Genome Data Viewer
    Location:
    50A3-50A3; 2-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13393705..13394667)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9281210..9282172)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Baramicin A2 Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Influence of Cannabinoids on Drosophila Behaviors, Longevity, and Traumatic Injury Responses of the Adult Nervous System. Candib A, et al. Cannabis Cannabinoid Res, 2024 Jun. PMID 37158809,
    2. Using Drosophila as an integrated model to study mild repetitive traumatic brain injury. Barekat A, et al. Sci Rep, 2016 May 4. PMID 27143646, Free PMC Article
    3. Ovarian tumors in Rbp9 mutants of Drosophila induce an immune response. Kim J, et al. Mol Cells, 2006 Oct 31. PMID 17085976
    4. Primary structure and in vitro antibacterial properties of the Drosophila melanogaster attacin C Pro-domain. Rabel D, et al. J Biol Chem, 2004 Apr 9. PMID 14744858
    5. Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging. Wang M, et al. Aging (Albany NY), 2020 Jan 6. PMID 31907335, Free PMC Article

    See all (230) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data demonstrate an alphavirus antiviral response involving the Imd and Jak-STAT mediated expression of dptB and attC.
      Title: An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication.
    2. Study shows that the antimicrobial peptide, Attacin, is upregulated in Rbp9 mutants, especially in ovaries where tumors form.
      Title: Ovarian tumors in Rbp9 mutants of Drosophila induce an immune response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in humoral immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to bacterium HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Attacin-C
    Names
    AttC-PB
    Attacin-C precursor
    CG4740-PB
    attacin
    attacin C
    attacinC
    attackin
    drosophila immune induced molecule 16
    NP_523729.3
    • deletion mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13393705..13394667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079005.4 → NP_523729.3  Attacin-C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523729.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8ML72, Q95NH6, Q95NK2, Q95UA2, Q95UA3, Q95UA4, Q95UA5, Q9GPI3, Q9GPI4
      Conserved Domains (2) summary
      pfam03768
      Location:51 → 120
      Attacin_N; Attacin, N-terminal region
      pfam03769
      Location:122 → 240
      Attacin_C; Attacin, C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95NH6.1 Q95NH6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials