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    RIC-3 RIC3 acetylcholine receptor chaperone [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIC-3provided by FlyBase
    Official Full Name
    RIC3 acetylcholine receptor chaperoneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050296
    Locus tag
    Dmel_CG30296
    See related
    AllianceGenome:FB:FBgn0050296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15652; CG30296; CG30926; CG9349; Dmel\CG30296; DmRIC-3; Ric3
    Summary
    Predicted to enable unfolded protein binding activity. Involved in chaperone-mediated protein folding and protein maturation by protein folding. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Is expressed in adult head and adult heart. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See RIC-3 in Genome Data Viewer
    Location:
    57B9-57B12; 2-92 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21017784..21024918)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16905289..16912423)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene grauzone Neighboring gene uncharacterized protein Neighboring gene Souji Neighboring gene NADH dehydrogenase (ubiquinone) B14.7 subunit Neighboring gene long non-coding RNA:CR45148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues. Lansdell SJ, et al. J Neurochem, 2008 Jun. PMID 18208544
    2. Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions. Ihara M, et al. Proc Natl Acad Sci U S A, 2020 Jul 14. PMID 32611810, Free PMC Article
    3. Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids. Komori Y, et al. PLoS Genet, 2023 Feb. PMID 36795653, Free PMC Article
    4. Generation of Mutants from the 57B Region of Drosophila melanogaster. Steinmetz EL, et al. Genes (Basel), 2023 Nov 6. PMID 38002990, Free PMC Article
    5. Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors in Drosophila Neural Development and Physiology. Rosenthal JS, et al. Front Cell Neurosci, 2021. PMID 34650404, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables unfolded protein binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RIC3 acetylcholine receptor chaperone
    Names
    CG30296-PC
    CG30296-PD
    CG30296-PE
    CG30296-PG
    CG30296-PH
    CG30296-PI
    CG30296-PJ
    CG30296-PK
    CG30296-PL
    CG30296-PM
    CG30296-PN
    CG30296-PO
    CG30296-PP
    CG30296-PQ
    CG30296-PR
    CG30296-PS
    CG30296-PT
    CG30296-PU
    CG30296-PV
    RIC-3-PC
    RIC-3-PD
    RIC-3-PE
    RIC-3-PG
    RIC-3-PH
    RIC-3-PI
    RIC-3-PJ
    RIC-3-PK
    RIC-3-PL
    RIC-3-PM
    RIC-3-PN
    RIC-3-PO
    RIC-3-PP
    RIC-3-PQ
    RIC-3-PR
    RIC-3-PS
    RIC-3-PT
    RIC-3-PU
    RIC-3-PV

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21017784..21024918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103919.3 → NP_001097389.1  RIC3 acetylcholine receptor chaperone, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097389.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP4, Q058V3
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    2. NM_001274185.2 → NP_001261114.1  RIC3 acetylcholine receptor chaperone, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261114.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFX1
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    3. NM_001299730.1 → NP_001286659.1  RIC3 acetylcholine receptor chaperone, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286659.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH23
      Conserved Domains (2) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3
      pfam16515
      Location:290 → 330
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    4. NM_137693.4 → NP_611537.2  RIC3 acetylcholine receptor chaperone, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611537.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP4, Q9W2N4
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    5. NM_001169756.2 → NP_001163227.1  RIC3 acetylcholine receptor chaperone, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP4, E1JGP2
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    6. NM_001169750.2 → NP_001163221.1  RIC3 acetylcholine receptor chaperone, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP6, E1JGP3
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    7. NM_001169755.2 → NP_001163226.1  RIC3 acetylcholine receptor chaperone, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163226.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP5, E1JGP4
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    8. NM_001169752.2 → NP_001163223.1  RIC3 acetylcholine receptor chaperone, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163223.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP9, E1JGP5
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    9. NM_001169754.2 → NP_001163225.1  RIC3 acetylcholine receptor chaperone, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163225.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP7, E1JGP6
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    10. NM_001169751.2 → NP_001163222.1  RIC3 acetylcholine receptor chaperone, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163222.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPQ0, E1JGP7
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    11. NM_001169753.2 → NP_001163224.1  RIC3 acetylcholine receptor chaperone, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP8, E1JGP8
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    12. NM_166418.4 → NP_726018.2  RIC3 acetylcholine receptor chaperone, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726018.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPQ3, Q9W2N3
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    13. NM_001169759.2 → NP_001163230.1  RIC3 acetylcholine receptor chaperone, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPQ1, E1JGP9
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    14. NM_001169757.2 → NP_001163228.1  RIC3 acetylcholine receptor chaperone, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPQ4, E1JGQ0
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    15. NM_001169758.2 → NP_001163229.1  RIC3 acetylcholine receptor chaperone, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163229.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPQ2, E1JGQ1
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    16. NM_206188.4 → NP_995910.2  RIC3 acetylcholine receptor chaperone, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995910.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP9, E1JGP5
      Conserved Domains (1) summary
      pfam15361
      Location:33 → 184
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    17. NM_001103921.3 → NP_001097391.1  RIC3 acetylcholine receptor chaperone, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP4, Q9W2N4
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    18. NM_001274184.2 → NP_001261113.1  RIC3 acetylcholine receptor chaperone, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261113.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP4, Q9W2N4
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3

    19. NM_001299729.1 → NP_001286658.1  RIC3 acetylcholine receptor chaperone, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286658.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8YPP5, E1JGP4
      Conserved Domains (1) summary
      pfam15361
      Location:145 → 224
      RIC3; Resistance to inhibitors of cholinesterase homologue 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFX1 A0A0B4KFX1
    A0A0B4LH23 A0A0B4LH23
    E1JGP2 E1JGP2
    E1JGP3 E1JGP3
    E1JGP4 E1JGP4
    E1JGP5 E1JGP5
    E1JGP6 E1JGP6
    E1JGP7 E1JGP7
    E1JGP8 E1JGP8
    E1JGP9 E1JGP9
    E1JGQ0 E1JGQ0
    E1JGQ1 E1JGQ1
    Q058V3 Q058V3
    Q9W2N3 Q9W2N3
    Q9W2N4 Q9W2N4

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