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    CG7646 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7646provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036926
    Locus tag
    Dmel_CG7646
    See related
    AllianceGenome:FB:FBgn0036926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey160; BcDNA:RH69723; Dmel\CG7646
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of signal transduction. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to human GUCA1A (guanylate cyclase activator 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7646 in Genome Data Viewer
    Location:
    76D8-76D8; 3-46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19991887..19996269)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19984987..19989369)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene schumacher-levy Neighboring gene antisense RNA:CR45161 Neighboring gene CMP-sialic acid synthase Neighboring gene flightin Neighboring gene Neurocalcin Neighboring gene gamma-aminobutyric acid transaminase Neighboring gene Translocase of outer membrane 20 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurocalcin regulates nighttime sleep and arousal in Drosophila. Chen KF, et al. Elife, 2019 Mar 13. PMID 30865587, Free PMC Article
    2. Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation. Haussmann IU, et al. Dev Biol, 2010 Dec 15. PMID 20854801
    3. Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains. Kollmar M. BMC Genomics, 2006 Jul 20. PMID 16857047, Free PMC Article
    4. Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. Ueda HR, et al. J Biol Chem, 2002 Apr 19. PMID 11854264
    5. Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. Esslinger SM, et al. RNA Biol, 2013 Jun. PMID 23669073, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7646-PA
    CG7646-PB
    CG7646-PC
    Frequenin1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19991887..19996269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300195.1 → NP_001287124.1  uncharacterized protein Dmel_CG7646, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW66
      Conserved Domains (1) summary
      COG5126
      Location:18 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_176364.2 → NP_788542.1  uncharacterized protein Dmel_CG7646, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788542.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYT0
      Related
      FBpp0074670
      Conserved Domains (1) summary
      cd00051
      Location:1 → 65
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. NM_140910.4 → NP_649167.1  uncharacterized protein Dmel_CG7646, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW66
      Related
      FBpp0074669
      Conserved Domains (1) summary
      COG5126
      Location:18 → 178
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MYT0 Q8MYT0
    Q9VW66 Q9VW66

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