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    Bin1 Bicoid interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bin1provided by FlyBase
    Official Full Name
    Bicoid interacting protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024491
    Locus tag
    Dmel_CG6046
    See related
    AllianceGenome:FB:FBgn0024491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    150001_at; BcDNA:RE02417; Bin 1; bin1; BIN1; bin1/dSAP18; CG6046; Dmel\CG6046; dsap18; dSap18; dSAP18; sap18; SAP18
    Summary
    Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in heterochromatin formation and negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including antennal anlage; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human SAP18 (Sin3A associated protein 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bin1 in Genome Data Viewer
    Location:
    89B7-89B7; 3-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16186156..16189564, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12011878..12012619, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43472 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sarah Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial single stranded DNA-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster SAP18 protein is required for environmental stress responses. Costa E, et al. FEBS Lett, 2011 Jan 21. PMID 21146528
    2. Exploring the Phenotypic Space and the Evolutionary History of a Natural Mutation in Drosophila melanogaster. Ullastres A, et al. Mol Biol Evol, 2015 Jul. PMID 25862139, Free PMC Article
    3. Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing. Costa E, et al. Chromosome Res, 2006. PMID 16823614
    4. SAP18 promotes Krüppel-dependent transcriptional repression by enhancer-specific histone deacetylation. Matyash A, et al. J Biol Chem, 2009 Jan 30. PMID 19049982
    5. Identification of drosophila bicoid-interacting proteins using a custom two-hybrid selection. Zhu W, et al. Gene, 2000 Mar 21. PMID 10717484

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
      Title: The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.
    2. PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Abeta42 toxicity.
      Title: PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity.
    3. The findings reveal the ability of Bin1 to modify actin dynamics and provide a possible mechanistic connection between Bin1 and tau-induced pathobiological changes of the actin cytoskeleton.
      Title: Bin1 directly remodels actin dynamics through its BAR domain.
    4. dSAP18 is a key player in transcriptional responses to stress.
      Title: Drosophila melanogaster SAP18 protein is required for environmental stress responses.
    5. Kruppel tethers the SAP18 bound histone deacetylase complex 1 at distinct enhancer elements, which causes repression via histone H3 deacetylation
      Title: SAP18 promotes Krüppel-dependent transcriptional repression by enhancer-specific histone deacetylation.
    6. removal of maternal sap18 results in embryos that are missing labrally derived parts of the cephalopharyngeal skeleton
      Title: Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster.
    7. Drosophila dSAP18 protein is a nuclear protein that associates with chromosomes and the nuclear matrix and interacts with pinin involved in RNA splicing.
      Title: Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bicoid interacting protein 1
    Names
    Bin1-PA
    Bin1-PB
    Bin1-PC
    CG6046-PA
    CG6046-PB
    CG6046-PC
    SIN3-associated polypeptide 18
    Sin3A-associated polypeptide p18

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16186156..16189564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316512.1 → NP_001303441.1  bicoid interacting protein 1, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1LYZ7, Q8SZF6, Q9N9Z3, Q9VEX9
      UniProtKB/TrEMBL
      A0A126GUU7
      Conserved Domains (1) summary
      pfam06487
      Location:22 → 134
      SAP18; Sin3 associated polypeptide p18 (SAP18)

    2. NM_001316511.1 → NP_001303440.1  bicoid interacting protein 1, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1LYZ7, Q8SZF6, Q9N9Z3, Q9VEX9
      UniProtKB/TrEMBL
      A0A126GUU7
      Conserved Domains (1) summary
      pfam06487
      Location:22 → 134
      SAP18; Sin3 associated polypeptide p18 (SAP18)

    3. NM_079653.3 → NP_524377.1  bicoid interacting protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1LYZ7, Q8SZF6, Q9N9Z3, Q9VEX9
      UniProtKB/TrEMBL
      A0A126GUU7
      Related
      FBpp0082731
      Conserved Domains (1) summary
      pfam06487
      Location:22 → 134
      SAP18; Sin3 associated polypeptide p18 (SAP18)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUU7 A0A126GUU7
    Q9VEX9.1 Q9VEX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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