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    CG6154 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6154provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039420
    Locus tag
    Dmel_CG6154
    See related
    AllianceGenome:FB:FBgn0039420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6154
    Summary
    Predicted to enable metallodipeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult head. Human ortholog(s) of this gene implicated in hepatoblastoma. Orthologous to several human genes including DPEP1 (dipeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6154 in Genome Data Viewer
    Location:
    97A7-97A7; 3-90 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26262662..26277050)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22088384..22102772)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46061 Neighboring gene long non-coding RNA:CR46062 Neighboring gene antisense RNA:CR44321 Neighboring gene Aldolase 1 Neighboring gene long non-coding RNA:CR42765 Neighboring gene oskyddad Neighboring gene Nilkantha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. Scarpati M, et al. PLoS One, 2019. PMID 30753230, Free PMC Article
    2. LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila. Marcogliese PC, et al. Hum Mol Genet, 2017 Apr 1. PMID 28158614, Free PMC Article
    3. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Kim YW, et al. Alzheimers Dement, 2021 May. PMID 33576571, Free PMC Article
    4. Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. Mazloomian A, et al. RNA Biol, 2015. PMID 26512413, Free PMC Article
    5. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Stampfel G, et al. Nature, 2015 Dec 3. PMID 26550828

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6154-PC
    CG6154-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26262662..26277050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143214.2 → NP_651471.2  uncharacterized protein Dmel_CG6154, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651471.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR24, Q9VBG1
      Conserved Domains (1) summary
      pfam01244
      Location:61 → 396
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    2. NM_170267.2 → NP_733146.2  uncharacterized protein Dmel_CG6154, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733146.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR24, Q9VBG1
      Conserved Domains (1) summary
      pfam01244
      Location:61 → 396
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBG1 Q9VBG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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