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    Trax Translin associated factor X [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Traxprovided by FlyBase
    Official Full Name
    Translin associated factor Xprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038327
    Locus tag
    Dmel_CG5063
    See related
    AllianceGenome:FB:FBgn0038327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5063; Dmel\CG5063; trax; TRAX
    Summary
    Enables RNA endonuclease activity. Located in cytoplasm. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain; embryonic central brain neurons; and ganglia. Orthologous to human TSNAX (translin associated factor X). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trax in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15361692..15362850)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11187414..11188540)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene Autophagy-related 4b Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene Component of oligomeric golgi complex 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex. Tian Y, et al. Nat Struct Mol Biol, 2011 Jun. PMID 21552261, Free PMC Article
    2. Structural insights into Drosophila-C3PO complex assembly and 'Dynamic Side Port' model in substrate entry and release. Mo X, et al. Nucleic Acids Res, 2018 Sep 19. PMID 29860349, Free PMC Article
    3. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Liu Y, et al. Science, 2009 Aug 7. PMID 19661431, Free PMC Article
    4. Functional characterization of Drosophila Translin and Trax. Claussen M, et al. Genetics, 2006 Nov. PMID 17028328, Free PMC Article
    5. The long and short of antiviral defense: small RNA-based immunity in insects. Bronkhorst AW, et al. Curr Opin Virol, 2014 Aug. PMID 24732439

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings indicate that the loss of Translin/TRAX complex (dmC3PO) promoted the accumulation of the passenger strand of esi-2.1 (hp-CG4068B) and increased the accumulation of miR-bantam.
      Title: Opposite effects of Drosophila C3PO on gene silencing mediated by esi-2.1 and miRNA-bantam.
    2. These studies establish that Trax adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.
      Title: Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
    3. an RNAi regulator that we term C3PO (component 3 promoter of RISC), a complex of Translin and Trax was purified; C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removing siRNA passenger strand cleavage products
      Title: C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.
    4. A translin null mutant was generated and a trax nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax.
      Title: Functional characterization of Drosophila Translin and Trax.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translin associated factor X
    Names
    CG5063-PB
    CG5063-PC
    Translin-associated factor X
    Trax-PB
    Trax-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15361692..15362850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142197.5 → NP_650454.2  translin associated factor X, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQD7, Q1W1G2, Q8INE1, Q961W6, Q9VF77
      Conserved Domains (1) summary
      cd14805
      Location:37 → 267
      Translin-like; Translin and translin-associated factor-X (TRAX)

    2. NM_169650.3 → NP_732021.2  translin associated factor X, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732021.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQD7, Q1W1G2, Q8INE1, Q961W6, Q9VF77
      Conserved Domains (1) summary
      cd14805
      Location:37 → 267
      Translin-like; Translin and translin-associated factor-X (TRAX)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K5N5 Q7K5N5
    Q9VF77 Q9VF77

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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