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    Apt1 Acyl-protein thioesterase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Apt1provided by FlyBase
    Official Full Name
    Acyl-protein thioesterase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0042138
    Locus tag
    Dmel_CG18815
    See related
    AllianceGenome:FB:FBgn0042138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey232; APT1; CG18815; Dmel\CG18815
    Summary
    Enables serine hydrolase activity. Predicted to be involved in protein depalmitoylation. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; central nervous system; germ layer; and supraesophageal ganglion. Orthologous to several human genes including LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Apt1 in Genome Data Viewer
    Location:
    68D1-68D1; 3-36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11628037..11630749)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11621137..11623849)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene PCI domain-containing protein 2 Neighboring gene mir-3642 stem loop Neighboring gene long non-coding RNA:CR45158 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472
    2. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article
    3. MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Flynt AS, et al. Mol Cell, 2010 Jun 25. PMID 20620959, Free PMC Article
    4. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
    5. Proteomic characterization of a temperature-sensitive conditional lethal in Drosophila melanogaster. Pedersen KS, et al. Heredity (Edinb), 2010 Feb. PMID 19812620

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. likely cytoplasmic thioesterase
      Title: The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-protein thioesterase 1
    Names
    Apt1-PA
    Apt1-PB
    Apt1-PC
    Apt1-PD
    Apt1-PE
    CG18815-PA
    CG18815-PB
    CG18815-PC
    CG18815-PD
    CG18815-PE
    NP_001261718.1
    NP_001261719.1
    NP_652674.1
    NP_996055.1
    NP_996056.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11628037..11630749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274789.1 → NP_001261718.1  Acyl-protein thioesterase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PDF4
      Conserved Domains (1) summary
      pfam02230
      Location:4 → 214
      Abhydrolase_2; Phospholipase/Carboxylesterase

    2. NM_001274790.1 → NP_001261719.1  Acyl-protein thioesterase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261719.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV64, M9PEW1
      Conserved Domains (1) summary
      pfam02230
      Location:4 → 214
      Abhydrolase_2; Phospholipase/Carboxylesterase

    3. NM_144417.3 → NP_652674.1  Acyl-protein thioesterase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7R0
      Related
      FBpp0075834
      Conserved Domains (1) summary
      pfam02230
      Location:4 → 214
      Abhydrolase_2; Phospholipase/Carboxylesterase

    4. NM_206334.2 → NP_996056.1  Acyl-protein thioesterase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7R0
      Conserved Domains (1) summary
      pfam02230
      Location:4 → 214
      Abhydrolase_2; Phospholipase/Carboxylesterase

    5. NM_206333.2 → NP_996055.1  Acyl-protein thioesterase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7R0
      Conserved Domains (1) summary
      pfam02230
      Location:4 → 214
      Abhydrolase_2; Phospholipase/Carboxylesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0PDF4 C0PDF4
    M9PEW1 M9PEW1
    Q9I7R0 Q9I7R0

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