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    ATPsynE ATP synthase, subunit E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATPsynEprovided by FlyBase
    Official Full Name
    ATP synthase, subunit Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038224
    Locus tag
    Dmel_CG3321
    See related
    AllianceGenome:FB:FBgn0038224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-88Bd; ATPJ; c550; CG3321; Dmel\CG3321
    Summary
    Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis and proton transmembrane transport. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in adult head; adult heart; and spermatozoon. Orthologous to human ATP5ME (ATP synthase membrane subunit e). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ATPsynE in Genome Data Viewer
    Location:
    88B4-88B4; 3-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14326947..14327735)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10152669..10153457)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Corazonin Neighboring gene SET domain containing 8 Neighboring gene Aftiphilin Neighboring gene spindle B Neighboring gene NK7.1 Neighboring gene Dynein axonemal assembly factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. Teixeira FK, et al. Nat Cell Biol, 2015 May. PMID 25915123, Free PMC Article
    2. Hundreds of putatively functional small open reading frames in Drosophila. Ladoukakis E, et al. Genome Biol, 2011 Nov 25. PMID 22118156, Free PMC Article
    3. Base Editing of Somatic Cells Using CRISPR-Cas9 in Drosophila. Marr E, et al. CRISPR J, 2021 Dec. PMID 34813372, Free PMC Article
    4. Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism. Grice SJ, et al. PLoS Genet, 2015 Mar. PMID 25816101, Free PMC Article
    5. okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Ghabrial A, et al. Genes Dev, 1998 Sep 1. PMID 9732269, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		  
    part_of proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase, subunit E
    Names
    ATP synthase e chain
    ATPsynE-PA
    ATPsynE-PB
    ATPsynE-PC
    CG3321-PA
    CG3321-PB
    CG3321-PC
    F0/F1 ATP synthase E
    complex Ve

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14326947..14327735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202292.1 → NP_001189221.1  ATP synthase, subunit E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77134
      Conserved Domains (1) summary
      pfam05680
      Location:3 → 76
      ATP-synt_E; ATP synthase E chain

    2. NM_169579.2 → NP_731903.1  ATP synthase, subunit E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77134
      Related
      FBpp0082391
      Conserved Domains (1) summary
      pfam05680
      Location:3 → 76
      ATP-synt_E; ATP synthase E chain

    3. NM_142099.3 → NP_650356.1  ATP synthase, subunit E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77134
      Related
      FBpp0082390
      Conserved Domains (1) summary
      pfam05680
      Location:3 → 76
      ATP-synt_E; ATP synthase E chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77134 O77134

    Gene LinkOut

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