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    NELF-B NELF-B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NELF-Bprovided by FlyBase
    Official Full Name
    NELF-Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027553
    Locus tag
    Dmel_CG32721
    See related
    AllianceGenome:FB:FBgn0027553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH10333; CG12152; CG32721; Dmel\CG32721; NELF; NelfB
    Summary
    Predicted to enable RNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; negative regulation of transcription elongation by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NELF complex. Is expressed in adult head and organism. Orthologous to human NELFB (negative elongation factor complex member B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NELF-B in Genome Data Viewer
    Location:
    7B7-7B7; 1-20 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7725996..7728361, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7620029..7622394, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hira Neighboring gene uncharacterized protein Neighboring gene Pyruvate dehydrogenase phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ChIPping away at the Drosophila clock. Zhou J, et al. Methods Enzymol, 2015. PMID 25662463
    2. Defining the status of RNA polymerase at promoters. Core LJ, et al. Cell Rep, 2012 Oct 25. PMID 23062713, Free PMC Article
    3. Promoter proximal pausing and the control of gene expression. Li J, et al. Curr Opin Genet Dev, 2011 Apr. PMID 21324670, Free PMC Article
    4. Reconstitution of factor-dependent, promoter proximal pausing in Drosophila nuclear extracts. Li J, et al. Methods Mol Biol, 2015. PMID 25665561
    5. NELF-A controls Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance. Ngian ZK, et al. Aging Cell, 2021 May. PMID 33788376, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NELF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NELF complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription repressor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NELF-B
    Names
    CG32721-PA
    NELF-B-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7725996..7728361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132174.3 → NP_572402.1  NELF-B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y113
      Related
      FBpp0071034
      Conserved Domains (1) summary
      pfam06209
      Location:116 → 588
      COBRA1; Cofactor of BRCA1 (COBRA1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y113.1 Q9Y113

    Gene LinkOut

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