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    peb pebbled [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pebprovided by FlyBase
    Official Full Name
    pebbledprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003053
    Locus tag
    Dmel_CG12212
    See related
    AllianceGenome:FB:FBgn0003053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-4Cg; CG12212; Dmel\CG12212; EG:66A1.1; EP55; Hin; Hind; hnd; hnt; Hnt; HNT; Peb; PEB
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell morphogenesis involved in neuron differentiation; embryonic development via the syncytial blastoderm; and positive regulation of cell-cell adhesion. Located in nucleus and polytene chromosome. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; peripheral nervous system; presumptive embryonic/larval system; and tracheal primordium. Orthologous to human RREB1 (ras responsive element binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See peb in Genome Data Viewer
    Location:
    4C10-4C10; 1-8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4617564..4627206)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4511597..4521239)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32773 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Alstrom syndrome 1b Neighboring gene Alstrom syndrome 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of hindsight in sensory organ precursors is associated with a transformation of campaniform sensilla to microchaetae in the Drosophila wing. Szablewski K, et al. MicroPubl Biol, 2019 May 20. PMID 32550447, Free PMC Article
    2. A Method for Rapid Selection of Randomly Induced Mutations in a Gene of Interest Using CRISPR/Cas9 Mediated Activation of Gene Expression. Ng WA, et al. G3 (Bethesda), 2020 Jun 1. PMID 32312838, Free PMC Article
    3. Clonal dominance in excitable cell networks. Alsous JI, et al. Nat Phys, 2021 Dec. PMID 35242199, Free PMC Article
    4. Asymmetric segregation of Numb and Prospero during cell division. Knoblich JA, et al. Nature, 1995 Oct 19. PMID 7566172
    5. ovo, a Drosophila gene required for ovarian development, is specifically expressed in the germline and shares most of its coding sequences with shavenbaby, a gene involved in embryo patterning. Mével-Ninio M, et al. Mech Dev, 1995 Jan. PMID 7748792

    See all (277) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hnt is the positive regulator of EGFR signaling.
      Title: A Functional Analysis of the Drosophila Gene hindsight: Evidence for Positive Regulation of EGFR Signaling.
    2. Here, the authors identify a zinc-finger transcription factor Hindsight (Hnt) as the first transcription factor regulating follicle's competency for ovulation in Drosophila.
      Title: The zinc-finger transcription factor Hindsight regulates ovulation competency of Drosophila follicles.
    3. Peb is expressed in developing and mature sensory neurons, suggesting it is required to establish or maintain their competence to undergo axon death.
      Title: Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration.
    4. HNT regulates R-cell axon targeting through transcriptional regulation of multiple genes
      Title: Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in axon guidance in Drosophila.
    5. Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control
      Title: Drosophila Hindsight and mammalian RREB-1 are evolutionarily conserved DNA-binding transcriptional attenuators.
    6. Hindsight functions in the determined R1/R6 precursor cells to allow Delta transcription to reach high enough levels at the right time to induce the cone-cell determinants Prospero and D-Pax2 in neighboring cells
      Title: Hindsight modulates Delta expression during Drosophila cone cell induction.
    7. essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape
      Title: Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1.
    8. Our studies suggest that Hindsight bridges the two antagonistic pathways, Notch and Hedgehog, in the temporal regulation of follicle-cell proliferation and differentiation.
      Title: Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amnioserosa maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of ommatidial planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in maintenance of epithelial integrity, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell-cell adhesion involved in epithelium migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of homophilic cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pebbled
    Names
    CG12212-PA
    CG12212-PB
    hindsight
    peb-PA
    peb-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4617564..4627206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014722.2 → NP_001014722.1  pebbled, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3V3, Q9W4J1
      Conserved Domains (4) summary
      COG3827
      Location:1299 → 1430
      PopZ; Cell pole-organizing protein PopZ [Cell cycle control, cell division, chromosome partitioning]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1453 → 1473
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1718 → 1742
      zf-H2C2_2; Zinc-finger double domain

    2. NM_057326.5 → NP_476674.3  pebbled, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476674.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3V3, Q9W4J1
      Related
      FBpp0070648
      Conserved Domains (4) summary
      COG3827
      Location:1299 → 1430
      PopZ; Cell pole-organizing protein PopZ [Cell cycle control, cell division, chromosome partitioning]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1453 → 1473
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1718 → 1742
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46205 O46205
    Q7K3V3 Q7K3V3
    Q9W4J1 Q9W4J1

    Gene LinkOut

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