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    Amacr Alpha-methylacyl-CoA racemase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amacrprovided by FlyBase
    Official Full Name
    Alpha-methylacyl-CoA racemaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032881
    Locus tag
    Dmel_CG9319
    See related
    AllianceGenome:FB:FBgn0032881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38E.13; AMACR; CG9319; Dmel\CG9319
    Summary
    Predicted to enable alpha-methylacyl-CoA racemase activity. Predicted to be involved in bile acid metabolic process. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in alpha-methylacyl-CoA racemase deficiency; congenital bile acid synthesis defect 4; and urinary bladder cancer. Orthologous to human AMACR (alpha-methylacyl-CoA racemase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Amacr in Genome Data Viewer
    Location:
    38E6-38E6; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20750934..20752341, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20750934..20752341, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Carcinine transporter Neighboring gene Transmembrane 9 superfamily protein member 2 Neighboring gene Female sterile (2) Ketel Neighboring gene Nucleostemin 4 Neighboring gene RHAU helicase Neighboring gene diaphanous

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster. Widmer YF, et al. Genetics, 2018 Aug. PMID 29925565, Free PMC Article
    2. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article
    3. A Systematic Cell-Based Analysis of Localization of Predicted Drosophila Peroxisomal Proteins. Baron MN, et al. Traffic, 2016 May. PMID 26865094
    4. Rosy Beginnings: Studying Peroxisomes in Drosophila. Pridie C, et al. Front Cell Dev Biol, 2020. PMID 32984330, Free PMC Article
    5. Peroxisome Protein Prediction in Drosophila melanogaster. Anderson-Baron M, et al. Subcell Biochem, 2018. PMID 30378026

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-methylacyl-CoA racemase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-methylacyl-CoA racemase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid alpha-oxidation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Alpha-methylacyl-CoA racemase
    Names
    Amacr-PA
    Amacr-PB
    CG9319-PA
    CG9319-PB
    NP_001260638.1
    NP_610054.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20750934..20752341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273709.1 → NP_001260638.1  Alpha-methylacyl-CoA racemase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIK0
      Conserved Domains (1) summary
      COG1804
      Location:2 → 365
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    2. NM_136210.3 → NP_610054.1  Alpha-methylacyl-CoA racemase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIK0
      Related
      FBpp0080989
      Conserved Domains (1) summary
      COG1804
      Location:2 → 365
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRF0 Q8MRF0
    Q9VIK0 Q9VIK0

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