Vps2 Vacuolar protein sorting 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vps2provided by FlyBase
Official Full Name: Vacuolar protein sorting 2provided by FlyBase
Primary source: FLYBASE:FBgn0039402
Locus tag: Dmel_CG14542
See related: AllianceGenome:FB:FBgn0039402
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14542; Did4; Dmel\CG14542; DmVPS2; dvps2; Dvps2; NEST:bs02f06; vps2
Summary: Involved in endosome transport via multivesicular body sorting pathway and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Colocalizes with early endosome and multivesicular body. Orthologous to human CHMP2A (charged multivesicular body protein 2A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26052821..26054128)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21878543..21879850)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

the expression of vps2 must be precisely regulated to maintain the normal structure of early endosomes.
Title: Loss- and gain-of-function analyses of vacuolar protein sorting 2 in Notch signaling of Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in endosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome transport via multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral entry into host cell	HMP more info	PubMed
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT III complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
colocalizes_with early endosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with multivesicular body	IDA Inferred from Direct Assay more info	PubMed