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    DENR Density regulated protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DENRprovided by FlyBase
    Official Full Name
    Density regulated proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030802
    Locus tag
    Dmel_CG9099
    See related
    AllianceGenome:FB:FBgn0030802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9099; Dmel\CG9099
    Summary
    Enables mRNA 5'-UTR binding activity. Involved in positive regulation of ecdysone receptor signaling pathway; positive regulation of insulin receptor signaling pathway; and translation reinitiation. Part of protein-containing complex. Is expressed in several structures, including adult heart; embryonic/larval fat body; embryonic/larval gut; embryonic/larval salivary gland; and larval integumentary system. Orthologous to human DENR (density regulated re-initiation and release factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DENR in Genome Data Viewer
    Location:
    15B4-15B4; 1-56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16885546..16886560, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16779579..16780593, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nitrogen permease regulator-like 2 Neighboring gene long non-coding RNA:CR43768 Neighboring gene RNA polymerase III subunit I Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-canonical initiation factors modulate repeat-associated non-AUG translation. Green KM, et al. Hum Mol Genet, 2022 Aug 17. PMID 35220421, Free PMC Article
    2. DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth. Schleich S, et al. Nature, 2014 Aug 14. PMID 25043021, Free PMC Article
    3. Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Vasudevan D, et al. Nat Commun, 2020 Sep 16. PMID 32938929, Free PMC Article
    4. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article
    5. Comparative transcriptional analysis uncovers molecular processes in early and mature somatic cyst cells of Drosophila testes. Adashev VE, et al. Eur J Cell Biol, 2022 Jun-Aug. PMID 35667338

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ecdysone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation reinitiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation reinitiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    density regulated protein
    Names
    CG9099-PA
    CG9099-PB
    DENR-PA
    DENR-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16885546..16886560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272701.1 → NP_001259630.1  density regulated protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SJ6, Q9VX98
      Conserved Domains (1) summary
      cl00229
      Location:26 → 183
      eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins

    2. NM_132948.4 → NP_573176.1  density regulated protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573176.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SJ6, Q9VX98
      Related
      FBpp0074121
      Conserved Domains (1) summary
      cl00229
      Location:26 → 183
      eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX98.3 Q9VX98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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