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    lap like-AP180 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lapprovided by FlyBase
    Official Full Name
    like-AP180provided by FlyBase
    Primary source
    FLYBASE:FBgn0086372
    Locus tag
    Dmel_CG2520
    See related
    AllianceGenome:FB:FBgn0086372
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AP180; BcDNA:GM10787; CG2520; dAP-3; Dmel\CG2520; EP(3)3060; EP3060; l(3)neo34; Lap; LAP; lap/AP180; sig
    Summary
    Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including clathrin-dependent synaptic vesicle endocytosis; neuron-neuron synaptic transmission; and positive regulation of clathrin-dependent endocytosis. Located in clathrin-coated pit. Is expressed in several structures, including adult head; adult heart; neuromuscular junction; presumptive embryonic/larval system; and spermatozoon. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lap in Genome Data Viewer
    Location:
    84D1-84D2; 3-48 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7186994..7200941)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3012716..3026663)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45909 Neighboring gene stranded at second Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endocytosis: an assembly protein for clathrin cages. McMahon HT. Curr Biol, 1999 May 6. PMID 10330371
    2. Quantal size and variation determined by vesicle size in normal and mutant Drosophila glutamatergic synapses. Karunanithi S, et al. J Neurosci, 2002 Dec 1. PMID 12451127, Free PMC Article
    3. PICALM modulates autophagy activity and tau accumulation. Moreau K, et al. Nat Commun, 2014 Sep 22. PMID 25241929, Free PMC Article
    4. [Drosophila melanogaster gene Merlin interacts with the clathrin adaptor protein gene lap]. Kopyl SA, et al. Genetika, 2010 Mar. PMID 20391775
    5. Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Zhang B, et al. Neuron, 1998 Dec. PMID 9883738

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Abeta42 toxicity.
      Title: PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity.
    2. results reveal a new mode by which AP180 couples protein retrieval to CME of SVs
      Title: AP180 couples protein retrieval to clathrin-mediated endocytosis of synaptic vesicles.
    3. clathrin adapter protein
      Title: [Drosophila melanogaster gene Merlin interacts with the clathrin adaptor protein gene lap].
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron-neuron synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    like-AP180
    Names
    CG2520-PA
    CG2520-PC
    CG2520-PD
    CG2520-PE
    CG2520-PF
    CG2520-PG
    CG2520-PH
    CG2520-PI
    CG2520-PJ
    EP3060
    Like-AP180
    complementation group 12
    lap-PA
    lap-PC
    lap-PD
    lap-PE
    lap-PF
    lap-PG
    lap-PH
    lap-PI
    lap-PJ
    like AP180
    saisoog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7186994..7200941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275410.1 → NP_001262339.1  like-AP180, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFE2, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:682 → 761
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain

    2. NM_001170067.2 → NP_001163538.1  like-AP180, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3H4, E1JJ78
      Conserved Domains (2) summary
      smart00818
      Location:694 → 773
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain

    3. NM_001144547.3 → NP_001138019.2  like-AP180, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138019.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0U7, C1C3H4
      Conserved Domains (1) summary
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain

    4. NM_001260031.2 → NP_001246960.1  like-AP180, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6V2, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:579 → 658
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain

    5. NM_079528.3 → NP_524252.2  like-AP180, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524252.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96528, Q8MQM1, Q9VI75
      Related
      FBpp0081091
      Conserved Domains (1) summary
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain

    6. NM_001275409.1 → NP_001262338.1  like-AP180, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGC6, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:610 → 689
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 287
      ANTH; ANTH domain

    7. NM_001275411.1 → NP_001262340.1  like-AP180, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF90, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:584 → 663
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 287
      ANTH; ANTH domain

    8. NM_001260030.2 → NP_001246959.1  like-AP180, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K631, C1C3H4
      Conserved Domains (2) summary
      smart00818
      Location:591 → 670
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain

    9. NM_001260029.2 → NP_001246958.1  like-AP180, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K603
      Conserved Domains (1) summary
      pfam07651
      Location:21 → 298
      ANTH; ANTH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K603 A0A0B4K603
    A0A0B4K631 A0A0B4K631
    A0A0B4K6V2 A0A0B4K6V2
    A0A0B4KF90 A0A0B4KF90
    A0A0B4KFE2 A0A0B4KFE2
    A0A0B4KGC6 A0A0B4KGC6
    B7Z0U7 B7Z0U7
    E1JJ78 E1JJ78
    Q9VI75.3 Q9VI75

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