Ran Ran [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ranprovided by FlyBase
Official Full Name: Ranprovided by FlyBase
Primary source: FLYBASE:FBgn0020255
Locus tag: Dmel_CG1404
See related: AllianceGenome:FB:FBgn0020255
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF30287; CG1404; Dmel\CG1404; dran; l(1)G0075; Q9VZ23; ran; RAN; ran10A; RanGTP
Summary: Enables GTP binding activity. Involved in several processes, including microtubule cytoskeleton organization; nuclear pore complex assembly; and regulation of mitotic cell cycle. Located in cell cortex; mitotic spindle microtubule; and nucleus. Colocalizes with mitotic spindle. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 10A8-10A8; 1-33 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11144852..11148716, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11038885..11042749, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
Title: TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
Results demonstrate that Ran is associated with the resistance to and tolerance of multiple pesticides.
Title: Analysis of Ran related to pesticide resistance in Drosophila Kc cells.
RanGTP is required for meiotic spindle organization and the initiation of embryonic development.
Title: RanGTP is required for meiotic spindle organization and the initiation of embryonic development in Drosophila.
the Canoe Ras-association (RA) domains directly bind RanGTP
Title: Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.
Knockdown of the small G protein Ran, which is essential for nuclear transport, leads to an arrest of EcR in the cytoplasm, but does not prevent efficient nuclear import of the most important heterodimerization partner of EcR, ultraspiracle (Usp).
Title: The importance of exportin and Ran for nucleocytoplasmic shuttling of the ecdysteroid receptor.
the possibility that Dntf-2r and ran-like might be involved in genomic conflicts during spermatogenesis
Title: Convergently recruited nuclear transport retrogenes are male biased in expression and evolving under positive selection in Drosophila.
results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
Title: ISWI is a RanGTP-dependent MAP required for chromosome segregation.
anillin and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran
Title: Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran.
gtpase ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos
Title: Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ran

Names: CG1404-PA; CG1404-PB; CG1404-PC; CG1404-PD; Ran GTPase; Ran-PA; Ran-PB; Ran-PC; Ran-PD; ran

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

11144852..11148716 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298182.1 → NP_001285111.1 Ran, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285111.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NH14, Q9NHN9, Q9VZ23

UniProtKB/TrEMBL

A4V4A5

Conserved Domains (1) summary

PTZ00132
Location:2 → 216

PTZ00132; GTP-binding nuclear protein Ran; Provisional
NM_143712.4 → NP_651969.1 Ran, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651969.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NH14, Q9NHN9, Q9VZ23

UniProtKB/TrEMBL

A4V4A5

Related

FBpp0073328

Conserved Domains (1) summary

PTZ00132
Location:2 → 216

PTZ00132; GTP-binding nuclear protein Ran; Provisional
NM_001298183.1 → NP_001285112.1 Ran, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285112.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NH14, Q9NHN9, Q9VZ23

UniProtKB/TrEMBL

A4V4A5

Conserved Domains (1) summary

PTZ00132
Location:2 → 216

PTZ00132; GTP-binding nuclear protein Ran; Provisional
NM_167272.3 → NP_727499.1 Ran, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727499.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NH14, Q9NHN9, Q9VZ23

UniProtKB/TrEMBL

A4V4A5

Related

FBpp0073327

Conserved Domains (1) summary

PTZ00132
Location:2 → 216

PTZ00132; GTP-binding nuclear protein Ran; Provisional