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    Tango2 Transport and Golgi organization 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tango2provided by FlyBase
    Official Full Name
    Transport and Golgi organization 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0030503
    Locus tag
    Dmel_CG11176
    See related
    AllianceGenome:FB:FBgn0030503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11176; Dmel\CG11176; TANGO2
    Summary
    Involved in Golgi organization and protein secretion. Located in Golgi apparatus and cytosol. Is expressed in organism. Used to study TANGO2-related metabolic encephalopathy and arrythmias. Human ortholog(s) of this gene implicated in TANGO2-related metabolic encephalopathy and arrythmias. Orthologous to human TANGO2 (transport and golgi organization 2 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tango2 in Genome Data Viewer
    Location:
    12A8-12A8; 1-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13616989..13619207)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13511022..13513240)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ndc80 Neighboring gene BthD selenoprotein Neighboring gene toothrin Neighboring gene uncharacterized protein Neighboring gene NFAT nuclear factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vitamin B5, a coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells. Asadi P, et al. J Inherit Metab Dis, 2023 Mar. PMID 36502486, Free PMC Article
    2. Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control. Maurer GW, et al. PLoS Genet, 2020 Apr. PMID 32339168, Free PMC Article
    3. A neurogenetic mechanism of experience-dependent suppression of aggression. Ishii K, et al. Sci Adv, 2022 Sep 9. PMID 36070378, Free PMC Article
    4. Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila. Pedra JH, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15118106, Free PMC Article
    5. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transport and golgi organization 2
    Names
    CG11176-PA
    CG11176-PB
    CG11176-PC
    CG11176-PD
    Tango2-PA
    Tango2-PB
    Tango2-PC
    Tango2-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13616989..13619207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298288.1 → NP_001285217.1  transport and golgi organization 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDW0
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 318
      TANGO2; Transport and Golgi organization 2

    2. NM_132677.4 → NP_572905.1  transport and golgi organization 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572905.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6SV10, Q8T0H6, Q9VYA8
      UniProtKB/TrEMBL
      M9PEI3
      Related
      FBpp0073638
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 261
      TANGO2; Transport and Golgi organization 2

    3. NM_001272596.1 → NP_001259525.1  transport and golgi organization 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6SV10, Q8T0H6, Q9VYA8
      UniProtKB/TrEMBL
      M9PEI3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 261
      TANGO2; Transport and Golgi organization 2

    4. NM_001258725.2 → NP_001245654.1  transport and golgi organization 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDW0
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 318
      TANGO2; Transport and Golgi organization 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDW0 M9NDW0
    M9PEI3 M9PEI3
    Q9VYA8.2 Q9VYA8

    Gene LinkOut

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