His2Av Histone H2A variant [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: His2Avprovided by FlyBase
Official Full Name: Histone H2A variantprovided by FlyBase
Primary source: FLYBASE:FBgn0001197
Locus tag: Dmel_CG5499
See related: AllianceGenome:FB:FBgn0001197
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: *i H2av; 5499; CG5499; dHis2Av; Dmel\CG5499; gamma-H2Av; gamma-H2AV; gamma-H2AvD; gamma-His2Av; gamma-HIS2AV; gammaH2Av; gammaH2AV; gammaH2ax; gammaH2Ax; H2A; H2A.F/Z; H2a.V; H2A.V; H2A.X; H2A.Z; H2av; H2Av; H2AV; h2AvD; H2avD; H2AvD; H2AV_DROM; H2AX; H2AZ; his; His; HIS; His2; His2A; his2av; his2Av; His2av; His2aV; His2AV; HIS2AV; His2AvD; HIS2AVD; HisH2Av; Hist; Hist2av; l(3)05146; l(3)810; l(3)97Dd; l(3)L1602; P-H2Av
Summary: Predicted to be a structural constituent of chromatin. Involved in several processes, including male germ-line stem cell population maintenance; negative regulation of peptidoglycan recognition protein signaling pathway; and somatic stem cell population maintenance. Located in chromosome and nucleus. Part of nucleosome. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; germline cell; and sensory nervous system primordium. Orthologous to several human genes including H2AZ1 (H2A.Z variant histone 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 97D3-97D3; 3-92 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26866929..26869220)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22692651..22694942)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone variant H2A.Z regulates zygotic genome activation.
Title: Histone variant H2A.Z regulates zygotic genome activation.
Drosophila H2Av negatively regulates the activity of the IMD pathway via facilitating Relish SUMOylation.
Title: Drosophila H2Av negatively regulates the activity of the IMD pathway via facilitating Relish SUMOylation.
A plant-specific SWR1 chromatin-remodeling complex couples histone H2A.Z deposition with nucleosome sliding.
Title: A plant-specific SWR1 chromatin-remodeling complex couples histone H2A.Z deposition with nucleosome sliding.
H2Av continuously exchanges between lipid droplets.
Title: Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos.
H2Av or H3S10 phosphorylation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophila.
Title: H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation.
The nucleosome positioning sequence (NPS) patterns from H2A.Z nucleosomes differ from the NPS patterns from H2A nucleosomes. The purine-purine/pyrimidine-pyrimidine pattern of H2A.Z nucleosomes has major peaks shifted by 10 bp deviated from the H2A nucleosome pattern. The H2A and H2A.Z nucleosomes have different sequence preferences.
Title: Drosophila H2A and H2A.Z Nucleosome Sequences Reveal Different Nucleosome Positioning Sequence Patterns.
the H2AZ-like rather than the H2AX-like function of H2AV is primarily required for normal hematopoiesis.
Title: The role of variant histone H2AV in Drosophila melanogaster larval hematopoiesis.
The study reports the crystal structure of the H2A.Z-binding domain of Drosophila melanogaster YL1 (dYL1-Z) in complex with an H2A.Z-H2B dimer at 1.9-A resolution.
Title: Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1.
The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation.
Title: The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation.
nucleosomes present significant, context-specific barriers to RNAPII in vivo that can be tuned by the incorporation of H2A.Z
Title: Nucleosomes are context-specific, H2A.Z-modulated barriers to RNA polymerase.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1633 (e-PCR)
- UniSTS:41757

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to chromatin	IDA Inferred from Direct Assay more info	PubMed
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IMP Inferred from Mutant Phenotype more info	PubMed
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone H2A

Names: CG5499-PA; CG5499-PB; H2A; His2Av-PA; His2Av-PB; Histone-2A; Histone-2av; histone; histone; histone 2A; histone H2A.v; histone H2Av; histone2A; histone2Av; histone2AvD