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    CG9853 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9853provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086605
    Locus tag
    Dmel_CG9853
    See related
    AllianceGenome:FB:FBgn0086605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD21829; CG41469; Dmel\CG9853; Get4
    Old locus tag
    CG41469; Dmel_CG41469
    Summary
    Predicted to be involved in protein insertion into ER membrane. Predicted to be part of BAT3 complex. Predicted to be active in cytosol. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GET4 (guided entry of tail-anchored proteins factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9853 in Genome Data Viewer
    Location:
    82A5-82A5; 3-47.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4398381..4402027, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (224103..227749, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46139 Neighboring gene antisense RNA:CR45999 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45187 Neighboring gene lost

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective. Wilson EL, et al. Cell Death Dis, 2024 Mar 11. PMID 38467609, Free PMC Article
    2. A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin. Sinsimer KS, et al. Development, 2011 Aug. PMID 21752933, Free PMC Article
    3. Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State. Kobayashi H, et al. Mol Cell, 2019 Jan 3. PMID 30503771
    4. The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria. Ge DT, et al. Mol Cell, 2019 Jun 6. PMID 31076285, Free PMC Article
    5. Comparative interactome analysis of α-arrestin families in human and Drosophila. Lee KT, et al. Elife, 2024 Jan 25. PMID 38270169, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into ER membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of BAT3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9853-PA
    CG9853-PB
    CG9853-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4398381..4402027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300227.1 → NP_001287156.1  uncharacterized protein Dmel_CG9853, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287156.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VN19
      UniProtKB/TrEMBL
      A0A0B4LGQ8
      Conserved Domains (1) summary
      pfam04190
      Location:55 → 310
      DUF410; Protein of unknown function (DUF410)

    2. NM_001104210.1 → NP_001097680.1  uncharacterized protein Dmel_CG9853, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097680.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VN19
      UniProtKB/TrEMBL
      A0A0B4LGQ8
      Conserved Domains (1) summary
      pfam04190
      Location:55 → 310
      DUF410; Protein of unknown function (DUF410)

    3. NM_141207.5 → NP_649464.1  uncharacterized protein Dmel_CG9853, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VN19
      UniProtKB/TrEMBL
      A0A0B4LGQ8
      Related
      FBpp0078589
      Conserved Domains (1) summary
      pfam04190
      Location:55 → 310
      DUF410; Protein of unknown function (DUF410)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGQ8 A0A0B4LGQ8
    Q9VN19.1 Q9VN19

    Gene LinkOut

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