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    mod modulo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    modprovided by FlyBase
    Official Full Name
    moduloprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002780
    Locus tag
    Dmel_CG2050
    See related
    AllianceGenome:FB:FBgn0002780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0952/14; CG2050; Dmel\CG2050; Mod; Modulo; ms(3)100EF
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm and nucleolus. Part of protein-containing complex. Is expressed in several structures, including anterior-posterior subdivision of organism; cuboidal/columnar epithelium; gut section; mesoderm; and mitotic domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mod in Genome Data Viewer
    Location:
    100F2-100F2; 3-103 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (32052060..32054974)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27877782..27880696)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Poseidon Neighboring gene kurtz Neighboring gene Microtubule-associated protein 205

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila modifier of variegation modulo gene product binds specific RNA sequences at the nucleolus and interacts with DNA and chromatin in a phosphorylation-dependent manner. Perrin L, et al. J Biol Chem, 1999 Mar 5. PMID 10037720
    2. Modulo, a new maternally expressed Drosophila gene encodes a DNA-binding protein with distinct acidic and basic regions. Krejci E, et al. Nucleic Acids Res, 1989 Oct 25. PMID 2510126, Free PMC Article
    3. A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila. Chen CC, et al. PLoS One, 2012. PMID 23028777, Free PMC Article
    4. Dynamics of the sub-nuclear distribution of Modulo and the regulation of position-effect variegation by nucleolus in Drosophila. Perrin L, et al. J Cell Sci, 1998 Sep. PMID 9718368
    5. Genetic and molecular analysis of terminal deletions of chromosome 3R of Drosophila melanogaster. Laurenti P, et al. Gene, 1995 Mar 10. PMID 7890161

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. To analyze transcription factors involved in gene regulation by testis-specific TAF (tTAF), tTAF-dependent promoters were mapped and analyzed in silico. Core promoters show decreased AT content and enrichment with translation control element CAAAATTY. Transcriptome study of testes from male mutants for tTAF, Acj6, and Modulo implies the existence of a regulatory hierarchy of tTAF, Modulo and Acj6.
      Title: Evidence for a hierarchical transcriptional circuit in Drosophila male germline involving testis-specific TAF and two gene-specific transcription factors, Mod and Acj6.
    2. The nucleolar function of modulo which is regulating the assembly of the centromere by directing the localization of CAL1.[Modulo]
      Title: A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila.
    3. regulatory interactions among Modulo, Boule, and the meiotic-arrest genes integrate meiosis and spermatid differentiation in the male germ line
      Title: Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    modulo
    Names
    CG2050-PA
    CG2050-PC
    male sterile(3)100EF
    mod-PA
    mod-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      32052060..32054974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079875.3 → NP_524614.2  modulo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524614.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13469, Q9V9S2
      UniProtKB/TrEMBL
      A0A0B4K7G4
      Related
      FBpp0085233
      Conserved Domains (2) summary
      cd00590
      Location:342 → 411
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl17169
      Location:177 → 244
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001260472.2 → NP_001247401.1  modulo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13469, Q9V9S2
      UniProtKB/TrEMBL
      A0A0B4K7G4
      Conserved Domains (2) summary
      cd00590
      Location:342 → 411
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl17169
      Location:177 → 244
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7G4 A0A0B4K7G4
    P13469.2 P13469
    Q8IGX8 Q8IGX8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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