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    Zip48C Zinc/iron regulated transporter-related protein 48C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36273, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Zip48Cprovided by FlyBase
    Official Full Name
    Zinc/iron regulated transporter-related protein 48Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033665
    Locus tag
    Dmel_CG13189
    See related
    AllianceGenome:FB:FBgn0033665
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg13189; CG13189; Dmel\CG13189; dZip48C; ZIP48C
    Summary
    Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to be active in membrane. Is expressed in adult head; amnioserosa; embryonic Malpighian tubule; embryonic proventriculus; and embryonic/larval salivary gland. Orthologous to human SLC39A11 (solute carrier family 39 member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zip48C in Genome Data Viewer
    Location:
    48C5-48C5; 2-65 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11899517..11901394)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7787022..7788899)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene cutoff Neighboring gene ncRNA Neighboring gene Endoplasmic reticulum p60 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene Microcephalin Neighboring gene rebuf Neighboring gene long non-coding RNA:CR44305

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. Lee WS, et al. J Clin Invest, 2022 May 2. PMID 35499073, Free PMC Article
    2. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. Rickmyre JL, et al. J Cell Sci, 2007 Oct 15. PMID 17895362
    3. A role for the Drosophila zinc transporter Zip88E in protecting against dietary zinc toxicity. Richards CD, et al. PLoS One, 2017. PMID 28704512, Free PMC Article
    4. A fly's eye view of zinc homeostasis: Novel insights into the genetic control of zinc metabolism from Drosophila. Richards CD, et al. Arch Biochem Biophys, 2016 Dec 1. PMID 27453039
    5. What can flies tell us about zinc homeostasis? Xiao G, et al. Arch Biochem Biophys, 2016 Dec 1. PMID 27136711

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc/iron regulated transporter-related protein 48C
    Names
    CG13189-PA
    Zip48C-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11899517..11901394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136868.3 → NP_610712.1  Zinc/iron regulated transporter-related protein 48C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SWW2, Q9V633
      Related
      FBpp0087144
      Conserved Domains (1) summary
      COG0428
      Location:23 → 340
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SWW2 Q8SWW2

    Gene LinkOut

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