aurB aurora B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aurBprovided by FlyBase
Official Full Name: aurora Bprovided by FlyBase
Primary source: FLYBASE:FBgn0024227
Locus tag: Dmel_CG6620
See related: AllianceGenome:FB:FBgn0024227
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ABK; Aur; Aur B; AurB; AURKB; Aurora B; Aurora-B; CG6620; DmAIRK2; DmAurB; DmAuroraB; Dmel\CG6620; ial; Ial; IAL; ial/AurB; IAL1
Summary: Enables protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including female germ-line stem cell asymmetric division; midbody abscission; and mitotic chromosome condensation. Located in kinetochore; meiotic spindle midzone; and midbody. Part of chromosome passenger complex. Is expressed in several structures, including antennal anlage; female germline cell; ganglia; head epidermis primordium; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 32B2-32B2; 2-43 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10856797..10858094, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10856797..10858094, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin B1-Cdk1 localized at the spindle midzone in an Aurora B-dependent manner, with incompletely separated chromosomes showing the highest Cdk1 activity. Slowing down anaphase chromosome motion delayed Cyclin B1 degradation and mitotic exit in an Aurora B-dependent manner.
Title: Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk.
Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Title: Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia.
Regulation of Polo by Aurora B and Map205 is required for cytokinesis.
Title: Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B and Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Title: Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Title: Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Title: INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability.
Title: Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
This protein accumulates at the mid-zones of chromosome-free spindles.
Title: Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell asymmetric division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in midbody abscission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid biorientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in repair of mitotic kinetochore microtubule attachment defect	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora B

Names: AURORA-like; CG6620-PA; DmAuroraB; IplI-aurora-like kinase; aurB-PA; aurora; aurora B kinase; aurora-B; auroraB; dAurora B

NP_477336.1

EC 2.7.11.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10856797..10858094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057988.4 → NP_477336.1 aurora B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477336.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VKN7, Q9XTQ0

Related

FBpp0079769

Conserved Domains (1) summary

cd14007
Location:52 → 306

STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase