U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sras severas [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44002, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Srasprovided by FlyBase
    Official Full Name
    severasprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029121
    Locus tag
    Dmel_CG4852
    See related
    AllianceGenome:FB:FBgn0029121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4852; Dmel\CG4852; FAC2_DROME
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sras in Genome Data Viewer
    Location:
    64D3-64D3; 3-14 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5563774..5565103)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5556874..5558203)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sinuous Neighboring gene Succinyl-coenzyme A synthetase beta subunit, GDP-forming Neighboring gene bc10 Neighboring gene Msr-110 Neighboring gene small non-coding RNA 357

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Type II CAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metalloproteases. Pei J, et al. Trends Biochem Sci, 2001 May. PMID 11343912
    2. An ABC transporter controls export of a Drosophila germ cell attractant. Ricardo S, et al. Science, 2009 Feb 13. PMID 19213920, Free PMC Article
    3. miR-263a Regulates ENaC to Maintain Osmotic and Intestinal Stem Cell Homeostasis in Drosophila. Kim K, et al. Dev Cell, 2017 Jan 9. PMID 28017617, Free PMC Article
    4. Two independent duplications forming the Cyp307a genes in Drosophila. Sztal T, et al. Insect Biochem Mol Biol, 2007 Oct. PMID 17785192
    5. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    severas
    Names
    CG4852-PA
    Sras-PA
    prenyl protease type II
    NP_524673.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5563774..5565103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079934.3 → NP_524673.3  severas [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524673.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZZ3, Q9U1H8, Q9VRM4
      Related
      FBpp0076791
      Conserved Domains (2) summary
      COG1266
      Location:72 → 253
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam02517
      Location:147 → 249
      Abi; CAAX protease self-immunity
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U1H8.3 Q9U1H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous