Cryba1 crystallin, beta A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cryba1provided by RGD
Official Full Name: crystallin, beta A1provided by RGD
Primary source: RGD:2415
See related: EnsemblRapid:ENSRNOG00000008700 AllianceGenome:RGD:2415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BA3A1C; beta-A3
Summary: Predicted to enable identical protein binding activity. Predicted to be a structural constituent of eye lens. Involved in several processes, including lens development in camera-type eye; negative regulation of intracellular signal transduction; and positive regulation of anoikis. Used to study cataract; microphthalmia; and retinal detachment. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in cataract and cataract 10 multiple types. Orthologous to human CRYBA1 (crystallin beta A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 19.1), Adrenal (RPKM 17.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63106465..63113020, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (62608373..62614726, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65160777..65167504)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that strocytes deficient in betaA3/A1-crystallin protein exhibit altered levels of total and activated signal transducer and activator of transcription 3 (STAT3).
Title: βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.
These results suggest that the disappearance of the betaA3/A1-crystallin protein and, in addition, down-regulation of the Nufip2 gene as a consequence of gene rearrangement causes the HiSER phenotype.
Title: Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion and rearrangement of the Cryba1 gene.
expression of betaA3/A1-crystallin is controlled differentially in various eye tissues with lens being the site of greatest expression
Title: Expression of βA3/A1-crystallin in the developing and adult rat eye.
Mutation in the crystallin A1 gene impairs phagosome degradation in the retinal pigmented epithelium
Title: Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of eye lens	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in lens development in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
involved_in lens development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta-crystallin A3

Names: beta-A3 crystallin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.