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    Ppp1r3b protein phosphatase 1, regulatory subunit 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192280, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp1r3bprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 3Bprovided by RGD
    Primary source
    RGD:621600
    See related
    EnsemblRapid:ENSRNOG00000011474 AllianceGenome:RGD:621600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables [phosphorylase] phosphatase activity; enzyme binding activity; and protein phosphatase regulator activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Part of protein phosphatase type 1 complex. Orthologous to human PPP1R3B (protein phosphatase 1 regulatory subunit 3B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 440.7), Thymus (RPKM 128.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r3b in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (63533318..63545683, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (56830011..56842395, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (60415192..60427498, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553369 Neighboring gene uncharacterized LOC134482394 Neighboring gene uncharacterized LOC120097474 Neighboring gene uncharacterized LOC134482397 Neighboring gene ribosomal protein L21, pseudogene 23 Neighboring gene uncharacterized LOC134482395

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1. Doherty MJ, et al. FEBS Lett, 1995 Nov 20. PMID 7498521
    2. Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes. Zibrova D, et al. Biochem J, 2008 Jun 1. PMID 18298402
    3. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Browne GJ, et al. Biochem J, 2001 Dec 1. PMID 11716774, Free PMC Article
    4. Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography. Moorhead G, et al. FEBS Lett, 1995 Apr 3. PMID 7720853
    5. A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. Munro S, et al. FEBS J, 2005 Mar. PMID 15752363

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
      Title: Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables [phosphorylase] phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of glycogen catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in glycogen granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 3B
    Names
    33 kDa glycogen-binding protein
    PP1 subunit R4
    R4
    hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
    protein phosphatase 1 (GL-subunit)
    protein phosphatase 1 regulatory subunit 4
    protein phosphatase 1 subunit GL
    protein phosphatase 1, regulatory (inhibitor) subunit 3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434432.1 → NP_001421361.1  protein phosphatase 1 regulatory subunit 3B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016

    2. NM_001434433.1 → NP_001421362.1  protein phosphatase 1 regulatory subunit 3B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016

    3. NM_138912.3 → NP_620267.2  protein phosphatase 1 regulatory subunit 3B

      See identical proteins and their annotated locations for NP_620267.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q63759, Q6IN01
      UniProtKB/TrEMBL
      A6IVM9
      Related
      ENSRNOP00000108106.1, ENSRNOT00000148975.1
      Conserved Domains (1) summary
      pfam03370
      Location:126 → 231
      CBM_21; Carbohydrate/starch-binding module (family 21)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      63533318..63545683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253216.5 → XP_006253278.1  protein phosphatase 1 regulatory subunit 3B isoform X1

      UniProtKB/Swiss-Prot
      Q63759, Q6IN01
      UniProtKB/TrEMBL
      A6IVM9
      Conserved Domains (1) summary
      pfam03370
      Location:126 → 231
      CBM_21; Carbohydrate/starch-binding module (family 21)

    2. XM_006253215.4 → XP_006253277.1  protein phosphatase 1 regulatory subunit 3B isoform X1

      UniProtKB/Swiss-Prot
      Q63759, Q6IN01
      UniProtKB/TrEMBL
      A6IVM9
      Related
      ENSRNOP00000042713.2, ENSRNOT00000051720.4
      Conserved Domains (1) summary
      pfam03370
      Location:126 → 231
      CBM_21; Carbohydrate/starch-binding module (family 21)

    RNA

    1. XR_010058276.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IN01.1 GenPept UniProtKB/Swiss-Prot:Q6IN01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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