U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sar1a secretion associated Ras related GTPase 1A [ Mus musculus (house mouse) ]

    Gene ID: 20224, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sar1aprovided by MGI
    Official Full Name
    secretion associated Ras related GTPase 1Aprovided by MGI
    Primary source
    MGI:MGI:98230
    See related
    Ensembl:ENSMUSG00000020088 AllianceGenome:MGI:98230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sara; Sara1; 1600019H17Rik
    Summary
    Predicted to enable G protein activity and amino acid sensor activity. Acts upstream of or within negative regulation of cargo loading into COPII-coated vesicle and vesicle-mediated transport. Located in Golgi apparatus and sarcoplasmic reticulum. Is expressed in several structures, including genitourinary system; liver; nervous system; retina nuclear layer; and skeletal musculature. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 41.8), bladder adult (RPKM 39.2) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sar1a in Genome Data Viewer
    Location:
    10 B4; 10 32.26 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61516096..61529076)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61680285..61693297)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10613 Neighboring gene STARR-positive B cell enhancer ABC_E6861 Neighboring gene pyrophosphatase (inorganic) 1 Neighboring gene RIKEN cDNA 1700022H01 gene Neighboring gene STARR-positive B cell enhancer ABC_E9032 Neighboring gene STARR-positive B cell enhancer ABC_E1800 Neighboring gene trypsin domain containing 1 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 2 Neighboring gene STARR-seq mESC enhancer starr_26853 Neighboring gene macroH2A.2 histone

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular analysis of SAR1-related cDNAs from a mouse pituitary cell line. Shen KA, et al. FEBS Lett, 1993 Dec 13. PMID 8262187
    2. The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development. Chang HM, et al. PLoS One, 2014. PMID 25170969, Free PMC Article
    3. Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo. Tang VT, et al. Proc Natl Acad Sci U S A, 2024 May 7. PMID 38687799, Free PMC Article
    4. Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset. Mansur A, et al. Elife, 2023 Jul 11. PMID 37432316, Free PMC Article
    5. Vesicle budding from endoplasmic reticulum is involved in calsequestrin routing to sarcoplasmic reticulum of skeletal muscles. Nori A, et al. Biochem J, 2004 Apr 15. PMID 14728599, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
      Title: Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
    2. Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.
      Title: Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in COPII vesicle coating ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to leucine starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cargo loading into COPII-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of COPII vesicle coating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cargo loading into COPII-coated vesicle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of COPII vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    small COPII coat GTPase SAR1A; GTP-binding protein SAR1a
    Names
    SAR1 gene homolog A
    SAR1a gene homolog 1
    NP_001345416.1
    NP_001345417.1
    NP_001393258.1
    NP_001393259.1
    NP_001393260.1
    NP_001393261.1
    NP_001393262.1
    NP_001393263.1
    NP_001393264.1
    NP_001393265.1
    NP_001393266.1
    NP_001393267.1
    NP_001393268.1
    NP_001393269.1
    NP_033146.1
    XP_006513464.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358487.2 → NP_001345416.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      Consensus CDS
      CCDS23883.1
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4
      Conserved Domains (1) summary
      cd00879
      Location:3 → 197
      Sar1; Sar1 is an essential component of COPII vesicle coats

    2. NM_001358488.2 → NP_001345417.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      Consensus CDS
      CCDS23883.1
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4
      Conserved Domains (1) summary
      cd00879
      Location:3 → 197
      Sar1; Sar1 is an essential component of COPII vesicle coats

    3. NM_001406329.1 → NP_001393258.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4

    4. NM_001406330.1 → NP_001393259.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4

    5. NM_001406331.1 → NP_001393260.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4
      Related
      ENSMUSP00000151383.2, ENSMUST00000219506.2

    6. NM_001406332.1 → NP_001393261.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4

    7. NM_001406333.1 → NP_001393262.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4

    8. NM_001406334.1 → NP_001393263.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4

    9. NM_001406335.1 → NP_001393264.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4

    10. NM_001406336.1 → NP_001393265.1  small COPII coat GTPase SAR1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4

    11. NM_001406337.1 → NP_001393266.1  small COPII coat GTPase SAR1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      Q3TXJ4

    12. NM_001406338.1 → NP_001393267.1  small COPII coat GTPase SAR1A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      A0A1W2P6N3

    13. NM_001406339.1 → NP_001393268.1  small COPII coat GTPase SAR1A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124421
      UniProtKB/TrEMBL
      A0A1W2P6N3

    14. NM_001406340.1 → NP_001393269.1  small COPII coat GTPase SAR1A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124421

    15. NM_009120.4 → NP_033146.1  small COPII coat GTPase SAR1A isoform 1

      See identical proteins and their annotated locations for NP_033146.1

      Status: VALIDATED

      Source sequence(s)
      AC124421
      Consensus CDS
      CCDS23883.1
      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4
      Related
      ENSMUSP00000020285.9, ENSMUST00000020285.10
      Conserved Domains (1) summary
      cd00879
      Location:3 → 197
      Sar1; Sar1 is an essential component of COPII vesicle coats

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      61516096..61529076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513401.4 → XP_006513464.1  GTP-binding protein SAR1a isoform X1

      See identical proteins and their annotated locations for XP_006513464.1

      UniProtKB/TrEMBL
      Q3TXJ4, Q99JZ4
      Conserved Domains (1) summary
      cd00879
      Location:3 → 197
      Sar1; Sar1 is an essential component of COPII vesicle coats
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36536.1 GenPept UniProtKB/Swiss-Prot:P36536

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools