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    grpE stress response protein GrpE [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886497, updated on 12-Jun-2021

    Summary

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    Gene symbol
    grpE
    Gene description
    stress response protein GrpE
    Locus tag
    Rv0351
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (421709..422416)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene transcriptional regulator Neighboring gene hypothetical protein Neighboring gene chaperone protein DnaK Neighboring gene chaperone protein DnaJ Neighboring gene heat shock protein transcriptional repressor HspR Neighboring gene PPE family protein PPE7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mycobacterium tuberculosis GrpE, A Heat-Shock Stress Responsive Chaperone, Promotes Th1-Biased T Cell Immune Response via TLR4-Mediated Activation of Dendritic Cells. Kim WS, et al. Front Cell Infect Microbiol, 2018. PMID 29637049, Free PMC Article
    2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mycobacterium tuberculosis GrpE-stimulated dendritic cells induced the proliferation of GrpE-specific Th1-type effector/memory CD4(+)/CD8(+)CD44(high)CD62L(low) T cells from the spleen of Mtb-infected mice in a TLR4-dependent manner.
      Title: Mycobacterium tuberculosis GrpE, A Heat-Shock Stress Responsive Chaperone, Promotes Th1-Biased T Cell Immune Response via TLR4-Mediated Activation of Dendritic Cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    stress response protein GrpE
    NP_214865.1
    • HSP-70 cofactor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      421709..422416
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214865.1 stress response protein GrpE [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214865.1

      Status: PROVISIONAL

      Conserved Domains (2) summary
      PRK14142
      Location:7 → 229
      PRK14142; heat shock protein GrpE; Provisional
      cd00446
      Location:56 → 106
      GrpE; 2-helical coiled coil [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WMT5.1

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