U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    folC folylpolyglutamate synthase FolC [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885902, updated on 6-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    folC
    Gene description
    folylpolyglutamate synthase FolC
    Locus tag
    Rv2447c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000962.3 (2746135..2747598, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene C4-dicarboxylate-transport transmembrane protein DctA Neighboring gene ribonuclease E Neighboring gene integral membrane protein Neighboring gene nucleoside diphosphate kinase Neighboring gene valine--tRNA ligase Neighboring gene trans-acting enoyl reductase Neighboring gene resuscitation-promoting factor RpfE

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations of folC cause increased susceptibility to sulfamethoxazole in Mycobacterium tuberculosis. Wang R, et al. Sci Rep, 2021 Jan 14. PMID 33446754, Free PMC Article
    2. Phylogenetic and Structural Significance of Dihydrofolate Synthase (folC) Mutations in Drug-Resistant Mycobacterium tuberculosis. Cheng VW, et al. Microb Drug Resist, 2016 Oct. PMID 27082669
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations of folC cause increased susceptibility to sulfamethoxazole in Mycobacterium tuberculosis.
      Title: Mutations of folC cause increased susceptibility to sulfamethoxazole in Mycobacterium tuberculosis.
    2. Phylogenetic and structural significance of dihydrofolate synthase (folC) mutations in drug-resistant Mycobacterium tuberculosis has been reported.
      Title: Phylogenetic and Structural Significance of Dihydrofolate Synthase (folC) Mutations in Drug-Resistant Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    folylpolyglutamate synthase FolC
    NP_216963.1
    • folylpoly-gamma-glutamate synthetase (FPGS)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2746135..2747598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216963.1 folylpolyglutamate synthase FolC [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216963.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A654TIR3
      Conserved Domains (1) summary
      COG0285
      Location:21 → 487
      FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    2VOR_A.1
    I6Y0R5.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases