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    ppsD phthiocerol synthesis polyketide synthase type I PpsD [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 887172, updated on 11-Dec-2020

    Summary

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    Gene symbol
    ppsD
    Gene description
    phthiocerol synthesis polyketide synthase type I PpsD
    Locus tag
    Rv2934
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (3262248..3267731)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene fatty-acid--CoA ligase FadD26 Neighboring gene phthiocerol synthesis polyketide synthase type I PpsA Neighboring gene phthiocerol synthesis polyketide synthase type I PpsB Neighboring gene phthiocerol synthesis polyketide synthase type I PpsC Neighboring gene phthiocerol synthesis polyketide synthase type I PpsE Neighboring gene daunorubicin ABC transporter ATP-binding protein DrrA Neighboring gene daunorubicin ABC transporter permease DrrB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis. De Majumdar S, et al. BMC Genomics, 2019 Feb 12. PMID 30755157, Free PMC Article
    2. Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity. Kirksey MA, et al. Infect Immun, 2011 Jul. PMID 21576344, Free PMC Article
    3. Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis. Siméone R, et al. J Bacteriol, 2007 Jul. PMID 17468241, Free PMC Article
    4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A spontaneous mutation in the ppsD gene of Comp1 strain underlies down-modulation of the phthiocerol dimycocerosate locus which is associated with defects in permeability and infectivity as well as virulence attenuation in guinea pigs.
      Title: Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis.
    2. a spontaneous point mutation in the putative polyketide synthase results in a G44C amino acid substitution responsible for PDIM deficiency, virulence attenuation in NOS2-neg and wild-type C57BL/6 mice, and a growth advantage in vitro in liquid culture.
      Title: Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.
    3. Findings indicate that Rv2953 encodes a trans-acting enoyl reductase that acts with PpsD in phthiocerol and phenolphthiocerol biosynthesis.
      Title: Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    phthiocerol synthesis polyketide synthase type I PpsD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      3262248..3267731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217450.1 phthiocerol synthesis polyketide synthase type I PpsD [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217450.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P9WQE3
      UniProtKB/TrEMBL
      I6YAM7
      Conserved Domains (3) summary
      cd08955
      Location:1323 → 1656
      KR_2_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x)
      smart00823
      Location:1696 → 1785
      PKS_PP; Phosphopantetheine attachment site
      COG3321
      Location:36 → 1097
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WQE3.1

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