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    pks1 polyketide synthase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888122, updated on 6-Oct-2023

    Summary

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    Gene symbol
    pks1
    Gene description
    polyketide synthase
    Locus tag
    Rv2946c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (3291503..3296353, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene transposase Neighboring gene insertion sequence element IS1533 transposase Neighboring gene lipoprotein LppX Neighboring gene polyketide synthase Neighboring gene p-hydroxybenzoyl--AMP ligase Neighboring gene chorismate pyruvate-lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. Gande R, et al. J Biol Chem, 2004 Oct 22. PMID 15308633
    2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), have key roles in mycolic acid biosynthesis in Corynebacterianeae
      Title: Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    polyketide synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      3291503..3296353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217462.1 polyketide synthase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217462.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      F2GL66, Q7D6E1
      Conserved Domains (5) summary
      cd08956
      Location:1227 → 1484
      KR_3_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x)
      smart00823
      Location:1504 → 1588
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:942 → 1215
      PKS_ER; Enoylreductase
      COG3321
      Location:1 → 642
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cl21454
      Location:732 → 912
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P96285.4

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