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    otsB2 trehalose 6-phosphate phosphatase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888137, updated on 6-Oct-2023

    Summary

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    Gene symbol
    otsB2
    Gene description
    trehalose 6-phosphate phosphatase
    Locus tag
    Rv3372
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (3786314..3787489)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene error-prone DNA polymerase Neighboring gene diacyglycerol O-acyltransferase Neighboring gene enoyl-CoA hydratase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice. Korte J, et al. PLoS Pathog, 2016 Dec. PMID 27936238, Free PMC Article
    2. Biochemical characterization and ligand-binding properties of trehalose-6-phosphate phosphatase from Mycobacterium tuberculosis. Shi L, et al. Acta Biochim Biophys Sin (Shanghai), 2013 Oct. PMID 23903290
    3. [Identification of trehalose-phosphate phosphatase associated with drug-resistance from culture supernatants of isoniazid-resistant Mycobacterium tuberculosis]. Yue J, et al. Zhonghua Jie He He Hu Xi Za Zhi, 2004 Oct. PMID 16200872
    4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We found that otsB2 is essential for growth of M. tuberculosis in vitro as well as for the acute infection phase in mice following aerosol infection
      Title: Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
    2. by a combination of experimental and computational approaches, study addressed the conformational and biochemical characteristics of TPP
      Title: Biochemical characterization and ligand-binding properties of trehalose-6-phosphate phosphatase from Mycobacterium tuberculosis.
    3. Trehalose-phosphate phosphatase is involved in drug resistance of Mycobacterium tuberculosis.
      Title: [Identification of trehalose-phosphate phosphatase associated with drug-resistance from culture supernatants of isoniazid-resistant Mycobacterium tuberculosis].
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    trehalose 6-phosphate phosphatase
    NP_217889.1
    • trehalose-phosphatase (TPP)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      3786314..3787489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217889.1 trehalose 6-phosphate phosphatase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217889.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4MBV5
      Conserved Domains (2) summary
      COG0637
      Location:14 → 121
      YcjU; Beta-phosphoglucomutase or related phosphatase, HAD superfamily [Carbohydrate transport and metabolism, General function prediction only]
      TIGR00685
      Location:139 → 381
      T6PP; trehalose-phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WFZ5.1

    Gene LinkOut

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