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    pks13 polyketide synthase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886133, updated on 10-Oct-2024

    Summary

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    Gene symbol
    pks13
    Gene description
    polyketide synthase
    Locus tag
    Rv3800c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (4255945..4261146, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase FadE35 Neighboring gene insertion sequence element IS1557 transposase Neighboring gene propionyl-CoA carboxylase subunit beta AccD Neighboring gene long-chain-fatty-acid--AMP ligase FadD32 Neighboring gene membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis. Bon C, et al. BMC Biol, 2022 Jun 21. PMID 35729566, Free PMC Article
    2. Insights into structures of imidazo oxazines as potent polyketide synthase XIII inhibitors using molecular modeling techniques. B S, et al. J Recept Signal Transduct Res, 2020 Aug. PMID 32228125
    3. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Wilson R, et al. Nat Chem Biol, 2013 Aug. PMID 23770708, Free PMC Article
    4. Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13. Bergeret F, et al. J Biol Chem, 2012 Sep 28. PMID 22825853, Free PMC Article
    5. The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis. Gavalda S, et al. J Biol Chem, 2009 Jul 17. PMID 19436070, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.
      Title: Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.
    2. Insights into structures of imidazo oxazines as potent polyketide synthase XIII inhibitors using molecular modeling techniques.
      Title: Insights into structures of imidazo oxazines as potent polyketide synthase XIII inhibitors using molecular modeling techniques.
    3. M. tuberculosis Pks13 is required for mycolic acid biosynthesis
      Title: Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
    4. Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13
      Title: Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.
    5. Data show that the couple FadD32-(N-ACP(Pks13)) composes the initiation module of the mycolic condensation system.
      Title: The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    polyketide synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      4255945..4261146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_218317.1 polyketide synthase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_218317.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4M878
      Conserved Domains (5) summary
      smart00823
      Location:16 → 93
      PKS_PP; Phosphopantetheine attachment site
      COG3319
      Location:1470 → 1727
      EntF; Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism]
      COG3321
      Location:119 → 1258
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      PRK12467
      Location:1283 → 1571
      PRK12467; peptide synthase; Provisional
      pfam00550
      Location:1241 → 1287
      PP-binding; Phosphopantetheine attachment site
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    I6X8D2.1

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