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    cyp51 lanosterol 14-alpha demethylase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888819, updated on 6-Oct-2023

    Summary

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    Gene symbol
    cyp51
    Gene description
    lanosterol 14-alpha demethylase
    Locus tag
    Rv0764c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (856682..858037, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ferredoxin Neighboring gene oxidoreductase Neighboring gene cytochrome P450 Cyp123 Neighboring gene HTH-type transcriptional regulator Neighboring gene aldehyde dehydrogenase AldA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple drug binding modes in Mycobacterium tuberculosis CYP51B1. Lockart MM, et al. J Inorg Biochem, 2020 Apr. PMID 31982812, Free PMC Article
    2. Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET. Lepesheva GI, et al. Arch Biochem Biophys, 2007 Aug 15. PMID 17585868, Free PMC Article
    3. Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions. McLean KJ, et al. Biochemistry, 2006 Jul 11. PMID 16819841
    4. MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51. Zanno A, et al. Biochim Biophys Acta, 2005 Apr-May. PMID 15863094
    5. Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis. Matsuura K, et al. J Biol Chem, 2005 Mar 11. PMID 15611056

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple drug binding modes in Mycobacterium tuberculosis CYP51B1.
      Title: Multiple drug binding modes in Mycobacterium tuberculosis CYP51B1.
    2. The results confirm (1) functional importance of conformational motions in the MTCYP51 F/G segment and (2) applicability of FRET to monitor them in solution.
      Title: Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.
    3. CYP51 was purified to homogeneity and characterized.
      Title: Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
    4. Plays primary roles in determining strength of interactions with azoles
      Title: Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis.
    5. MT FdR forms a complex with MT ferredoxin and MT CYP51 that transfers electrons and effects the demethylation of lanosterol
      Title: MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    lanosterol 14-alpha demethylase
    NP_215278.1
    • Cytochrome P450 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      856682..858037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215278.1 lanosterol 14-alpha demethylase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215278.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4M3H8
      Conserved Domains (1) summary
      cd11042
      Location:34 → 446
      CYP51-like; cytochrome P450 family 51 and similar cytochrome P450s
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WPP9.1

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