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    Rv0888 hypothetical protein [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885210, updated on 6-Oct-2023

    Summary

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    Gene symbol
    Rv0888
    Gene description
    hypothetical protein
    Locus tag
    Rv0888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (987233..988705)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ferredoxin/ferredoxin--NADP reductase Neighboring gene hypothetical protein Neighboring gene citrate synthase 2 Neighboring gene HTH-type transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps. Dang G, et al. Front Immunol, 2018. PMID 29670633, Free PMC Article
    2. Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis. Dang G, et al. Sci Rep, 2016 Jan 8. PMID 26742696, Free PMC Article
    3. Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages. Speer A, et al. Mol Microbiol, 2015 Sep. PMID 26036301, Free PMC Article
    4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that extracellular sphingomyelinase Rv0888 of Mycobacterium tuberculosis contributes to pathological lung injury of Mycobacterium smegmatis in mice via Inducing formation of neutrophil extracellular traps
      Title: Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps.
    2. Mycobacterium tuberculosis Rv0888 is a novel extracellular nuclease and a virulence factor.
      Title: Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis.
    3. Rv0888 is a novel outer membrane protein that enables Mycobacterium tuberculosis to utilize sphingomyelin as a source of several essential nutrients during intracellular growth
      Title: Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    hypothetical protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      987233..988705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215403.1 hypothetical protein Rv0888 [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215403.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I7W4X5
      Conserved Domains (2) summary
      pfam17963
      Location:104 → 186
      Big_9; Bacterial Ig domain
      cl00490
      Location:343 → 478
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WKQ1.1

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