Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmd10provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 10provided by MGI
Primary source: MGI:MGI:1858898
See related: Ensembl:ENSMUSG00000031429 AllianceGenome:MGI:1858898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; cytoskeletal protein binding activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of protein metabolic process; and regulation of DNA-templated transcription. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in several cellular components, including cytoskeleton; neuron projection; and nucleus. Is expressed in limb and limb mesenchyme. Orthologous to human PSMD10 (proteasome 26S subunit, non-ATPase 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 11.2), placenta adult (RPKM 10.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F1; X 61.67 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (139849174..139857460, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (140948425..140956711, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study in APC and/or gankyrin-deficient mice revealed that gankyrin in epithelial cell contributes to the development of sporadic colorectal cancer by reducing the expression of c-Myc, a critical mediator of the APC signaling pathway, and interleukin-6.
Title: Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer.
These studies show that Gank protein promotes hepatocyte proliferation by elimination of tumor-suppressor proteins.
Title: Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
the present study clarified, at least partly, mechanisms of vascular tumorigenesis, and suggests that gankyrin might play a physiological role in hypoxic responses besides its roles as an oncoprotein.
Title: Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.
FXR prevents liver cancer by inhibiting the gankyrin promoter via C/EBPbeta-HDAC1 complexes, leading to subsequent protection of tumor suppressor proteins from degradation.
Title: Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.
Gankyrin is a key regulator of Ras-mediated activation of Akt through inhibition of the downstream RhoA/ROCK pathway and thus plays an essential role in Ras-induced tumorigenesis.
Title: Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.
Findings suggest that retinoblastoma protein degradation in Lmna-/- cells occurs by gankyrin and MDM2-independent mechanisms.
Title: Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.
Gankyrin oncoprotein has a role in progression of esophageal squamous cell carcinoma
Title: Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW554874 (e-PCR)
- UniSTS:181336

AI847977 (e-PCR)
- UniSTS:209543

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic sequestering of NF-kappaB	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic sequestering of NF-kappaB	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome regulatory particle assembly	ISO Inferred from Sequence Orthology more info
involved_in proteasome regulatory particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 10

Names: 26S proteasome regulatory subunit p28; gankyrin; proteasome subunit p28; proteosome (prosome, macropain) 26S subunit, non-ATPase, 10; proteosome subunit p28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164177.1 → NP_001157649.1 26S proteasome non-ATPase regulatory subunit 10 isoform 2

See identical proteins and their annotated locations for NP_001157649.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK136400, AV292699, BY057263, CD564300

Consensus CDS

CCDS53207.1

UniProtKB/TrEMBL

A2AG83

Related

ENSMUSP00000108602.2, ENSMUST00000112978.2

Conserved Domains (4) summary

cd00204
Location:36 → 150

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:44 → 136

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:10 → 60

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:39 → 70

ANK; ANK repeat [structural motif]
NM_016883.4 → NP_058579.2 26S proteasome non-ATPase regulatory subunit 10 isoform 1

See identical proteins and their annotated locations for NP_058579.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK136400, AV292699, BY057263

Consensus CDS

CCDS30444.1

UniProtKB/Swiss-Prot

Q8R0G2, Q9D383, Q9D7N8, Q9Z2X2

Related

ENSMUSP00000033805.9, ENSMUST00000033805.15

Conserved Domains (5) summary

cd00204
Location:36 → 159

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00023
Location:171 → 203

Ank; Ankyrin repeat

pfam12796
Location:44 → 136

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:10 → 60

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:39 → 70

ANK; ANK repeat [structural motif]