Eomes eomesodermin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eomesprovided by MGI
Official Full Name: eomesoderminprovided by MGI
Primary source: MGI:MGI:1201683
See related: Ensembl:ENSMUSG00000032446 AllianceGenome:MGI:1201683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tbr2; TBR-2
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and chromatin DNA binding activity. Involved in several processes, including gastrulation; nervous system development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including endodermal cell fate specification; nervous system development; and trophectodermal cell differentiation. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; gonad; limb; and limb bud. Orthologous to human EOMES (eomesodermin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E14 (RPKM 10.8), frontal lobe adult (RPKM 6.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 70.21 cM; 9 F3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (118307259..118315176)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (118478186..118486132)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells.
Title: The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells.
Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes.
Title: Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes.
Complex regulation of Eomes levels mediated through distinct functional features of the Meteor long non-coding RNA locus.
Title: Complex regulation of Eomes levels mediated through distinct functional features of the Meteor long non-coding RNA locus.
Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4[+] T cells.
Title: Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4(+) T cells.
The transcription factor Eomes promotes expression of inhibitory receptors on hepatic CD8(+) T cells during HBV persistence.
Title: The transcription factor Eomes promotes expression of inhibitory receptors on hepatic CD8(+) T cells during HBV persistence.
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes.
Title: Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes.
Characterization of Tbr2-expressing retinal ganglion cells.
Title: Characterization of Tbr2-expressing retinal ganglion cells.
EOMES is essential for antitumor activity of CD8(+) T cells in chronic lymphocytic leukemia.
Title: EOMES is essential for antitumor activity of CD8(+) T cells in chronic lymphocytic leukemia.
Impact of mTOR signaling pathway on CD8+ T cell immunity through Eomesodermin in response to invasive candidiasis.
Title: Impact of mTOR signaling pathway on CD8+ T cell immunity through Eomesodermin in response to invasive candidiasis.
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells.
Title: Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (22) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Eomes (e-PCR), detects polymorphism
- UniSTS:506881

RH126131 (e-PCR)
- UniSTS:162843

Eomes (e-PCR), detects polymorphism
- UniSTS:164908

Eomes (e-PCR), detects polymorphism
- UniSTS:508534

Eomes (e-PCR), detects polymorphism
- UniSTS:508550

Eomes (e-PCR), detects polymorphism
- UniSTS:464783

NoName (e-PCR)
- UniSTS:236277

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IC Inferred by Curator more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anatomical structure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation involved in embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cerebral cortex regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mesendoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal to mesenchymal transition involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophectodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within trophectodermal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within type II interferon production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eomesodermin homolog

Names: T-box brain protein 2; T-brain-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164789.2 → NP_001158261.1 eomesodermin homolog isoform 2

See identical proteins and their annotated locations for NP_001158261.1

Status: VALIDATED

Source sequence(s)

AC173340

Consensus CDS

CCDS52960.1

UniProtKB/Swiss-Prot

O54839

Related

ENSMUSP00000107393.2, ENSMUST00000111763.8

Conserved Domains (2) summary

cd00182
Location:269 → 462

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

pfam16176
Location:465 → 686

T-box_assoc; T-box transcription factor-associated
NM_001411153.1 → NP_001398082.1 eomesodermin homolog isoform 3

Status: VALIDATED

Source sequence(s)

AC173340

Related

ENSMUSP00000118079.2, ENSMUST00000150633.2
NM_010136.4 → NP_034266.2 eomesodermin homolog isoform 1

See identical proteins and their annotated locations for NP_034266.2

Status: VALIDATED

Source sequence(s)

AC173340

Consensus CDS

CCDS23603.1

UniProtKB/Swiss-Prot

O54839, Q3UPL1, Q52KJ1, Q8BN22, Q9JJL1, Q9QYG7

Related

ENSMUSP00000035020.9, ENSMUST00000035020.15

Conserved Domains (2) summary

cd00182
Location:269 → 462

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

pfam16176
Location:484 → 705

T-box_assoc; T-box transcription factor-associated