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    Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25391, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp2a3provided by RGD
    Official Full Name
    ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3provided by RGD
    Primary source
    RGD:2175
    See related
    EnsemblRapid:ENSRNOG00000017912 AllianceGenome:RGD:2175
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SERCA3
    Summary
    Enables P-type calcium transporter activity and calcium-dependent ATPase activity. Involved in calcium ion transmembrane transport; endoplasmic reticulum calcium ion homeostasis; and liver regeneration. Predicted to be located in organelle membrane and sarcoplasmic reticulum. Predicted to be active in membrane. Biomarker of hypertension. Orthologous to human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 358.8), Spleen (RPKM 327.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp2a3 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58079710..58111279)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57581742..57612758)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59528849..59560440)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene zinc finger ZZ-type and EF-hand domain containing 1 Neighboring gene U1 spliceosomal RNA Neighboring gene transfer RNA proline (anticodon GGG) 6 Neighboring gene purinergic receptor P2X 1 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Thermal instability of rat muscle sarcoplasmic reticulum Ca(2+)-ATPase function. Schertzer JD, et al. Am J Physiol Endocrinol Metab, 2002 Oct. PMID 12217889
    2. cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump. Burk SE, et al. J Biol Chem, 1989 Nov 5. PMID 2553713
    3. Platelet Ca(2+)ATPases : a plural, species-specific, and multiple hypertension-regulated expression system. Martin V, et al. Hypertension, 2000 Jan. PMID 10642281
    4. Expression of intracellular calcium channels and pumps after partial hepatectomy in rat. Magnino F, et al. Mol Cell Biol Res Commun, 2000 Jun. PMID 11032760
    5. The slippage of the Ca2+ pump and its control by anions and curcumin in skeletal and cardiac sarcoplasmic reticulum. Sumbilla C, et al. J Biol Chem, 2002 Apr 19. PMID 11844792

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The slippage of the Ca2+ pump and its control by anions and curcumin in skeletal and cardiac sarcoplasmic reticulum
      Title: The slippage of the Ca2+ pump and its control by anions and curcumin in skeletal and cardiac sarcoplasmic reticulum.
    2. novel sarco/endoplasmic isoforms; data suggest that the SERCA3 gene products have a more widespread role in cellular Ca2+ signaling than previously appreciated
      Title: Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family.
    3. Ca2+ uptake by the endoplasmic reticulum Ca2+-ATPase in rat microvascular endothelial cells
      Title: Ca2+ uptake by the endoplasmic reticulum Ca2+-ATPase in rat microvascular endothelial cells.
    4. Thermal instability of rat muscle sarcoplasmic reticulum Ca(2+)-ATPase function.
      Title: Thermal instability of rat muscle sarcoplasmic reticulum Ca(2+)-ATPase function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport from cytosol to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport from cytosol to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sarcoplasmic/endoplasmic reticulum calcium ATPase 3
    Names
    ATPase, Ca++ transporting, ubiquitous
    SR Ca(2+)-ATPase 3
    calcium pump 3
    NP_037046.1
    XP_038941200.2
    XP_063124535.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012914.1 → NP_037046.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3

      See identical proteins and their annotated locations for NP_037046.1

      Status: PROVISIONAL

      Source sequence(s)
      M30581
      UniProtKB/Swiss-Prot
      P18596, Q8R5I9
      UniProtKB/TrEMBL
      A6HGH2, G3V9U7
      Related
      ENSRNOP00000060512.2, ENSRNOT00000064840.5
      Conserved Domains (1) summary
      cd02083
      Location:5 → 989
      P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      58079710..58111279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268465.1 → XP_063124535.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1

      Related
      ENSRNOP00000104630.1, ENSRNOT00000146379.1

    2. XM_039085272.2 → XP_038941200.2  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18596.3 GenPept UniProtKB/Swiss-Prot:P18596

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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