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    Lrrc23 leucine rich repeat containing 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312707, updated on 27-Nov-2024

    Summary

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    Symbol
    Lrrc23provided by RGD
    Full Name
    leucine rich repeat containing 23provided by RGD
    Primary source
    RGD:1304779
    See related
    EnsemblRapid:ENSRNOG00000026309 AllianceGenome:RGD:1304779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrpb7
    Summary
    Predicted to be involved in flagellated sperm motility and radial spoke assembly. Predicted to be located in sperm flagellum. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in spermatogenic failure 92. Orthologous to human LRRC23 (leucine rich repeat containing 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 159.8), Thymus (RPKM 111.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc23 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159267572..159277764, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157581285..157592188, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157294386..157304590, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene atrophin 1 Neighboring gene uncharacterized LOC120102384 Neighboring gene enolase 2 Neighboring gene uncharacterized LOC134486638 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene cell division cycle associated 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunocytochemistry of neuron specific enolase (NSE) in the rat brain after single and repeated epileptic seizures. Yardimoğlu M, et al. Int J Neurosci, 2008 Jul. PMID 18569155
    2. The structure and expression of neuron-specific enolase gene. Sakimura K, et al. Gene, 1987. PMID 2450052
    3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in radial spoke assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 23
    Names
    leucine rich protein, B7
    leucine-rich repeat-containing protein 23-like
    neuron-specific enolase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394347.1 → NP_001381276.1  leucine-rich repeat-containing protein 23

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6ILK8, G3V9K7, Q6AYI9
      Related
      ENSRNOP00000051124.2, ENSRNOT00000051613.5
      Conserved Domains (2) summary
      sd00033
      Location:75 → 94
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:80 → 306
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159267572..159277764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286137.1 → XP_063142207.1  leucine-rich repeat-containing protein 23 isoform X1

      UniProtKB/TrEMBL
      M0RBN0
      Related
      ENSRNOP00000066972.2, ENSRNOT00000071593.4

    2. XM_063286138.1 → XP_063142208.1  leucine-rich repeat-containing protein 23 isoform X2

    RNA

    1. XR_005503236.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013165.2: Suppressed sequence

      Description
      NM_001013165.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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