Rab8b RAB8B, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab8bprovided by MGI
Official Full Name: RAB8B, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:2442982
See related: Ensembl:ENSMUSG00000036943 AllianceGenome:MGI:2442982
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5930437D16; D330025I23Rik
Summary: Predicted to enable several functions, including GDP binding activity; GTPase activity; and TPR domain binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of corticotropin secretion; and protein import into peroxisome membrane. Located in mitochondrion. Is expressed in brain; liver; and small intestine. Orthologous to human RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 15.7), liver E14.5 (RPKM 13.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 36.17 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (66750891..66826987, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (66843609..66919705, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab8b is involved in trafficking of WNV particles from recycling endosomes to the plasma membrane.
Title: Rab8b Regulates Transport of West Nile Virus Particles from Recycling Endosomes.
Simultaneous loss of Rab8a and Rab8b has little effect on ciliogenesis, whereas additional loss of Rab10 greatly affects ciliogenesis.
Title: Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.
Rab8b siRNA diminished autophagic killing of BCG, reduced the number of LC3 puncta in a high-content imaging analysis of cells stably expressing fluorescent protein fusion with LC3 and impeded basal clearance of the autophagic adaptor p62.
Title: TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation.
Otoferlin-Rab8b interaction links otoferlin to the basolateral endocytic and secretory trafficking.
Title: Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form.
These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
Title: The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

BE111188 (e-PCR)
- UniSTS:245622

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables TPR domain binding	IEA Inferred from Electronic Annotation more info
enables TPR domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate junction organization	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate junction organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome membrane	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell tip	IEA Inferred from Electronic Annotation more info
located_in cell tip	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-8B

Names: RAB44, member RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173413.3 → NP_775589.1 ras-related protein Rab-8B

See identical proteins and their annotated locations for NP_775589.1

Status: VALIDATED

Source sequence(s)

AC142504, BC059208, BY322741

Consensus CDS

CCDS23309.1

UniProtKB/Swiss-Prot

P61028, Q3U1Z3

UniProtKB/TrEMBL

Q0PD49

Related

ENSMUSP00000041857.8, ENSMUST00000041139.9

Conserved Domains (1) summary

cd01867
Location:6 → 172

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

66750891..66826987 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244336.2 → XP_030100196.1 ras-related protein Rab-8B isoform X1

Conserved Domains (1) summary

cl38936
Location:1 → 91

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases